19 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACTA2	Actin alpha 2, smooth muscle. (377 aa)
	COL6A3	Collagen type VI alpha 3 chain. (3111 aa)
	SPARC	Osteonectin. (303 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	AR	Androgen receptor. (891 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (410 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
	THBS1	Thrombospondin 1. (1218 aa)
	MMP9	Uncharacterized protein. (709 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	COL5A2	Collagen type V alpha 2 chain. (1252 aa)
	CTSK	Cathepsin K; Belongs to the peptidase C1 family. (330 aa)
	SERPINH1	Serpin family H member 1; Belongs to the serpin family. (418 aa)
	MARCKS	Myristoylated alanine rich protein kinase C substrate. (333 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	BGN	ENSCHIP00000018506	ENSCHIP00000003173	Actin alpha 2, smooth muscle.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.492
ACTA2	COL1A1	ENSCHIP00000018506	ENSCHIP00000023918	Actin alpha 2, smooth muscle.	Collagen type I alpha 1 chain.	0.803
ACTA2	COL1A2	ENSCHIP00000018506	ENSCHIP00000031191	Actin alpha 2, smooth muscle.	Collagen type I alpha 2 chain.	0.654
ACTA2	MMP9	ENSCHIP00000018506	ENSCHIP00000016938	Actin alpha 2, smooth muscle.	Uncharacterized protein.	0.557
AR	CASP3	ENSCHIP00000024342	ENSCHIP00000011490	Androgen receptor.	Caspase 3; Belongs to the peptidase C14A family.	0.661
AR	MMP9	ENSCHIP00000024342	ENSCHIP00000016938	Androgen receptor.	Uncharacterized protein.	0.509
BGN	ACTA2	ENSCHIP00000003173	ENSCHIP00000018506	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Actin alpha 2, smooth muscle.	0.492
BGN	COL1A1	ENSCHIP00000003173	ENSCHIP00000023918	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type I alpha 1 chain.	0.910
BGN	COL1A2	ENSCHIP00000003173	ENSCHIP00000031191	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type I alpha 2 chain.	0.824
BGN	COL5A2	ENSCHIP00000003173	ENSCHIP00000009695	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type V alpha 2 chain.	0.868
BGN	COL6A3	ENSCHIP00000003173	ENSCHIP00000019306	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type VI alpha 3 chain.	0.731
BGN	MMP9	ENSCHIP00000003173	ENSCHIP00000016938	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Uncharacterized protein.	0.568
BGN	SERPINH1	ENSCHIP00000003173	ENSCHIP00000001399	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Serpin family H member 1; Belongs to the serpin family.	0.518
BGN	SPARC	ENSCHIP00000003173	ENSCHIP00000023372	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Osteonectin.	0.720
BGN	THBS1	ENSCHIP00000003173	ENSCHIP00000018114	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Thrombospondin 1.	0.539
CASP3	AR	ENSCHIP00000011490	ENSCHIP00000024342	Caspase 3; Belongs to the peptidase C14A family.	Androgen receptor.	0.661
CASP3	COL1A1	ENSCHIP00000011490	ENSCHIP00000023918	Caspase 3; Belongs to the peptidase C14A family.	Collagen type I alpha 1 chain.	0.445
CASP3	CSF1	ENSCHIP00000011490	ENSCHIP00000033660	Caspase 3; Belongs to the peptidase C14A family.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.481
CASP3	MMP9	ENSCHIP00000011490	ENSCHIP00000016938	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.831
CASP3	PRKCD	ENSCHIP00000011490	ENSCHIP00000013998	Caspase 3; Belongs to the peptidase C14A family.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.923