STRINGSTRING
SOS1 SOS1 ATM ATM RETNLB RETNLB IFNG IFNG RPS6KA2 RPS6KA2 SPP1 SPP1 NANOG NANOG PTEN PTEN RPS6KA1 RPS6KA1 PCNA PCNA KRAS KRAS FOS FOS KITLG KITLG RRAS RRAS CD68 CD68 NRAS NRAS FOSL1 FOSL1 GAPDH GAPDH RETN RETN RRAS2 RRAS2 CD44 CD44 MAP2K1 MAP2K1 POU5F1 POU5F1 REXO1 REXO1 SOX17 SOX17 IL13 IL13 FLT1 FLT1 IL4 IL4 ALB ALB KLF4 KLF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
RETNLBUncharacterized protein. (101 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
RPS6KA2Ribosomal protein S6 kinase. (760 aa)
SPP1Uncharacterized protein. (279 aa)
NANOGHomeobox domain-containing protein. (300 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
RPS6KA1Ribosomal protein S6 kinase. (760 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
RRASRAS related. (218 aa)
CD68CD68 molecule. (335 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
RETNResistin. (109 aa)
RRAS2RAS related 2. (212 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
POU5F1POU domain protein. (360 aa)
REXO1RNA exonuclease 1 homolog. (1212 aa)
SOX17SRY-box transcription factor 17. (410 aa)
IL13Interleukin 13. (131 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
ALBSerum albumin. (608 aa)
KLF4Kruppel like factor 4. (510 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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