34 items (Capra hircus) - STRING interaction network

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second shell of interactors

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Your Input:
	COQ9	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (322 aa)
	PRKCH	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2. (543 aa)
	PXDN	Peroxidasin. (1525 aa)
	PDSS2	Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (412 aa)
	NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (727 aa)
	TST	Sulfurtransferase. (297 aa)
	NDUFS8	Uncharacterized protein. (212 aa)
	CMPK2	Cytidine/uridine monophosphate kinase 2. (458 aa)
	MTHFD2L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (347 aa)
	SQOR	Pyr_redox_2 domain-containing protein. (450 aa)
	COQ4	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (265 aa)
	IMPDH2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (586 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	AK4	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
	SUOX	Sulfite oxidase. (546 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
	ND6	NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
	ND3	NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (115 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (975 aa)
	AK5	Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa)
	NDUFS4	NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (344 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	NDUFB3	NADH:ubiquinone oxidoreductase subunit B3. (98 aa)
	MTHFD2	Uncharacterized protein. (352 aa)
	NDUFB9	NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (179 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	CTH	Cystathionine gamma-lyase. (415 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	NDUFS3	NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (266 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK4	AK5	ENSCHIP00000003491	ENSCHIP00000030909	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.958
AK4	CMPK2	ENSCHIP00000003491	ENSCHIP00000010184	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Cytidine/uridine monophosphate kinase 2.	0.504
AK4	IMPDH2	ENSCHIP00000003491	ENSCHIP00000008074	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.427
AK4	MTHFD1	ENSCHIP00000003491	ENSCHIP00000001307	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.	0.404
AK4	MTHFD2	ENSCHIP00000003491	ENSCHIP00000024076	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Uncharacterized protein.	0.425
AK4	MTHFD2L	ENSCHIP00000003491	ENSCHIP00000009047	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.527
AK4	SHMT2	ENSCHIP00000003491	ENSCHIP00000001693	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.406
AK4	SQOR	ENSCHIP00000003491	ENSCHIP00000008813	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	Pyr_redox_2 domain-containing protein.	0.537
AK5	AK4	ENSCHIP00000030909	ENSCHIP00000003491	Adenylate kinase 5; Belongs to the adenylate kinase family.	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.	0.958
AK5	CMPK2	ENSCHIP00000030909	ENSCHIP00000010184	Adenylate kinase 5; Belongs to the adenylate kinase family.	Cytidine/uridine monophosphate kinase 2.	0.563
AK5	MTHFD1	ENSCHIP00000030909	ENSCHIP00000001307	Adenylate kinase 5; Belongs to the adenylate kinase family.	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.	0.421
AK5	MTHFD2	ENSCHIP00000030909	ENSCHIP00000024076	Adenylate kinase 5; Belongs to the adenylate kinase family.	Uncharacterized protein.	0.409
AK5	MTHFD2L	ENSCHIP00000030909	ENSCHIP00000009047	Adenylate kinase 5; Belongs to the adenylate kinase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.554
AK5	PRKCH	ENSCHIP00000030909	ENSCHIP00000016683	Adenylate kinase 5; Belongs to the adenylate kinase family.	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...]	0.405
AK5	SHMT2	ENSCHIP00000030909	ENSCHIP00000001693	Adenylate kinase 5; Belongs to the adenylate kinase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.449
AK5	SQOR	ENSCHIP00000030909	ENSCHIP00000008813	Adenylate kinase 5; Belongs to the adenylate kinase family.	Pyr_redox_2 domain-containing protein.	0.548
CBS	CTH	ENSCHIP00000007198	ENSCHIP00000021417	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Cystathionine gamma-lyase.	0.999
CBS	IMPDH2	ENSCHIP00000007198	ENSCHIP00000008074	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.578
CBS	MTHFD1	ENSCHIP00000007198	ENSCHIP00000001307	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.	0.458
CBS	MTHFD1L	ENSCHIP00000007198	ENSCHIP00000032334	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.461