STRINGSTRING
VIM VIM PAX8 PAX8 LEP LEP PECAM1 PECAM1 KRT8 KRT8 RUNX2 RUNX2 ZEB1 ZEB1 PLAUR PLAUR RUNX1 RUNX1 LOX LOX NUPR1 NUPR1 HOXB7 HOXB7 UPK3A UPK3A TSPAN1 TSPAN1 KRT5 KRT5 PDGFRA PDGFRA PTEN PTEN CD3D CD3D BASP1 BASP1 NOG NOG HOXD13 HOXD13 PIEZO2 PIEZO2 INS INS RGN RGN KRT20 KRT20 CD74 CD74 ITGAM ITGAM KRT14 KRT14 EPCAM EPCAM PTPRC PTPRC LHX1 LHX1 FOXA1 FOXA1 APOE APOE CRYM CRYM PAX2 PAX2 SPINK1 SPINK1 HOXB13 HOXB13 KRT4 KRT4 GATA3 GATA3 KRT19 KRT19 RSPO1 RSPO1 KRT18 KRT18 SHH SHH SOX9 SOX9 AR AR COL1A1 COL1A1 NOTCH1 NOTCH1 SOX17 SOX17 KRT7 KRT7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VIMVimentin; Belongs to the intermediate filament family. (471 aa)
PAX8Paired box 8. (457 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (739 aa)
KRT8Keratin 8; Belongs to the intermediate filament family. (484 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
PLAURPlasminogen activator, urokinase receptor. (331 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
LOXLysyl oxidase. (418 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
HOXB7Homeobox B7. (217 aa)
UPK3AUroplakin 3A. (287 aa)
TSPAN1Tetraspanin. (241 aa)
KRT5Keratin 5; Belongs to the intermediate filament family. (561 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
CD3DCD3d molecule. (167 aa)
BASP1Brain abundant membrane attached signal protein 1. (228 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HOXD13Homeobox D13. (340 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2736 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
RGNRegucalcin. (301 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (422 aa)
CD74CD74 molecule. (261 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (514 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
LHX1LIM homeobox 1. (406 aa)
FOXA1Forkhead box A1. (468 aa)
APOEApolipoprotein E. (326 aa)
CRYMCrystallin mu. (314 aa)
PAX2Paired box 2. (467 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
HOXB13Homeobox B13. (285 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (555 aa)
GATA3GATA binding protein 3. (467 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (399 aa)
RSPO1Ovarian R-spondin member 1. (262 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
SOX9SRY-box transcription factor 9. (525 aa)
ARAndrogen receptor. (891 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
NOTCH1Notch receptor 1. (2508 aa)
SOX17SRY-box transcription factor 17. (410 aa)
KRT7Keratin 7; Belongs to the intermediate filament family. (466 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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