(22 nodes) (2020) Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart ... network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOPX	Homeobox domain-containing protein. (73 aa)
	GDF1	TGF_BETA_2 domain-containing protein. (368 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (655 aa)
	PDLIM3	PDZ and LIM domain 3. (364 aa)
	FHL2	Four and a half LIM domains 2. (279 aa)
	NPPA	Natriuretic peptide A. (188 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	MYH7	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1955 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	TNNI3	Uncharacterized protein. (228 aa)
	TPM1	Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
	MYL2	Myosin light chain 2. (178 aa)
	ALB	Serum albumin. (608 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1248 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	TNNI1	Troponin I1, slow skeletal type. (187 aa)
	TBX2	T-box transcription factor 2. (771 aa)
	LOC102182562	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (359 aa)
	ACTN2	Actinin alpha 2. (902 aa)
	CD34	Uncharacterized protein. (384 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CSRP3	ENSCHIP00000006208	ENSCHIP00000026803	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.794
ACTN2	MYH7	ENSCHIP00000006208	ENSCHIP00000024142	Actinin alpha 2.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.910
ACTN2	MYL2	ENSCHIP00000006208	ENSCHIP00000021875	Actinin alpha 2.	Myosin light chain 2.	0.822
ACTN2	NKX2-5	ENSCHIP00000006208	ENSCHIP00000017688	Actinin alpha 2.	NK2 homeobox 5.	0.811
ACTN2	NPPA	ENSCHIP00000006208	ENSCHIP00000029669	Actinin alpha 2.	Natriuretic peptide A.	0.620
ACTN2	PDLIM3	ENSCHIP00000006208	ENSCHIP00000030476	Actinin alpha 2.	PDZ and LIM domain 3.	0.739
ACTN2	TNNI1	ENSCHIP00000006208	ENSCHIP00000016174	Actinin alpha 2.	Troponin I1, slow skeletal type.	0.861
ACTN2	TNNI3	ENSCHIP00000006208	ENSCHIP00000022616	Actinin alpha 2.	Uncharacterized protein.	0.859
ACTN2	TPM1	ENSCHIP00000006208	ENSCHIP00000022213	Actinin alpha 2.	Uncharacterized protein; Belongs to the tropomyosin family.	0.736
ALB	BMP4	ENSCHIP00000020234	ENSCHIP00000023678	Serum albumin.	Bone morphogenetic protein 4.	0.745
ALB	CD34	ENSCHIP00000020234	ENSCHIP00000002645	Serum albumin.	Uncharacterized protein.	0.856
ALB	JUN	ENSCHIP00000020234	ENSCHIP00000001903	Serum albumin.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.630
ALB	NPPA	ENSCHIP00000020234	ENSCHIP00000029669	Serum albumin.	Natriuretic peptide A.	0.579
BMP4	ALB	ENSCHIP00000023678	ENSCHIP00000020234	Bone morphogenetic protein 4.	Serum albumin.	0.745
BMP4	CD34	ENSCHIP00000023678	ENSCHIP00000002645	Bone morphogenetic protein 4.	Uncharacterized protein.	0.672
BMP4	NKX2-5	ENSCHIP00000023678	ENSCHIP00000017688	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.693
BMP4	TBX2	ENSCHIP00000023678	ENSCHIP00000012825	Bone morphogenetic protein 4.	T-box transcription factor 2.	0.542
CD34	ALB	ENSCHIP00000002645	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.856
CD34	BMP4	ENSCHIP00000002645	ENSCHIP00000023678	Uncharacterized protein.	Bone morphogenetic protein 4.	0.672
CSRP3	ACTN2	ENSCHIP00000026803	ENSCHIP00000006208	Cysteine and glycine rich protein 3.	Actinin alpha 2.	0.794