45 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MMP3	Matrix metallopeptidase 3. (477 aa)
	LOC102182683	C-X-C motif chemokine. (109 aa)
	MAOB	Amine oxidase. (366 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (411 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1607 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (500 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (565 aa)
	COL4A5	Collagen IV NC1 domain-containing protein. (568 aa)
	COL4A6	Collagen IV NC1 domain-containing protein. (170 aa)
	PLAU	Plasminogen activator, urokinase. (440 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	SPARCL1	SPARC like 1. (653 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
	VARS1	Valyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1276 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
	COL5A2	Collagen type V alpha 2 chain. (1252 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa)
	IFI44	Interferon induced protein 44. (429 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
	AOX1	Aldehyde oxidase 1. (1339 aa)
	SPP1	Uncharacterized protein. (279 aa)
	BST2	Uncharacterized protein. (156 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	IL10	Interleukin 10. (177 aa)
	MMP9	Uncharacterized protein. (709 aa)
	ISG15	Interferon-stimulated protein 17/ubiquitin cross-reactive protein. (157 aa)
	OASL	25A_SYNTH_3 domain-containing protein. (342 aa)
	IFI6	Interferon alpha inducible protein 6. (135 aa)
	CENPE	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2431 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (851 aa)
	PLAUR	Plasminogen activator, urokinase receptor. (331 aa)
	CDC20	WD_REPEATS_REGION domain-containing protein. (499 aa)
	LOC102188176	FAD-binding PCMH-type domain-containing protein. (1339 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	CXCR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (364 aa)
	KIF2C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (721 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1608 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
	COL14A1	Collagen type XIV alpha 1 chain. (1775 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH3A2	AOX1	ENSCHIP00000033843	ENSCHIP00000011353	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldehyde oxidase 1.	0.926
ALDH3A2	EGFR	ENSCHIP00000033843	ENSCHIP00000022759	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Receptor protein-tyrosine kinase.	0.482
ALDH3A2	LOC102188176	ENSCHIP00000033843	ENSCHIP00000022753	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	FAD-binding PCMH-type domain-containing protein.	0.930
ALDH3A2	MAOB	ENSCHIP00000033843	ENSCHIP00000029514	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Amine oxidase.	0.465
AOX1	ALDH3A2	ENSCHIP00000011353	ENSCHIP00000033843	Aldehyde oxidase 1.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.926
AOX1	LOC102188176	ENSCHIP00000011353	ENSCHIP00000022753	Aldehyde oxidase 1.	FAD-binding PCMH-type domain-containing protein.	0.903
APP	EGFR	ENSCHIP00000032622	ENSCHIP00000022759	Amyloid beta precursor protein.	Receptor protein-tyrosine kinase.	0.499
APP	IFNG	ENSCHIP00000032622	ENSCHIP00000016152	Amyloid beta precursor protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.442
APP	IL10	ENSCHIP00000032622	ENSCHIP00000016929	Amyloid beta precursor protein.	Interleukin 10.	0.436
APP	MMP9	ENSCHIP00000032622	ENSCHIP00000016938	Amyloid beta precursor protein.	Uncharacterized protein.	0.445
APP	PLAT	ENSCHIP00000032622	ENSCHIP00000000197	Amyloid beta precursor protein.	Plasminogen activator; Belongs to the peptidase S1 family.	0.532
APP	PLAU	ENSCHIP00000032622	ENSCHIP00000000686	Amyloid beta precursor protein.	Plasminogen activator, urokinase.	0.446
APP	PLG	ENSCHIP00000032622	ENSCHIP00000007843	Amyloid beta precursor protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.461
APP	SRC	ENSCHIP00000032622	ENSCHIP00000002619	Amyloid beta precursor protein.	Tyrosine-protein kinase.	0.482
BST2	IFI44	ENSCHIP00000013732	ENSCHIP00000010021	Uncharacterized protein.	Interferon induced protein 44.	0.697
BST2	IFI6	ENSCHIP00000013732	ENSCHIP00000018429	Uncharacterized protein.	Interferon alpha inducible protein 6.	0.555
BST2	ISG15	ENSCHIP00000013732	ENSCHIP00000017154	Uncharacterized protein.	Interferon-stimulated protein 17/ubiquitin cross-reactive protein.	0.765
BST2	OASL	ENSCHIP00000013732	ENSCHIP00000017691	Uncharacterized protein.	25A_SYNTH_3 domain-containing protein.	0.795
BST2	RSAD2	ENSCHIP00000013732	ENSCHIP00000024819	Uncharacterized protein.	Radical S-adenosyl methionine domain containing 2.	0.725
BST2	STAT1	ENSCHIP00000013732	ENSCHIP00000005767	Uncharacterized protein.	Signal transducer and activator of transcription.	0.626