(20 nodes) (2021) Capturing Cardiogenesis in Gastruloids. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	POLR2A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
	RYR2	Ryanodine receptor 2. (4943 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	CDX2	Caudal type homeobox 2. (306 aa)
	TBX5	T-box transcription factor 5. (594 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	NFATC1	Nuclear factor of activated T cells 1. (1002 aa)
	SOX17	SRY-box transcription factor 17. (410 aa)
	GATA6	GATA binding protein 6. (592 aa)
	SOX1	SRY-box transcription factor 1. (313 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	ACTB	Uncharacterized protein. (375 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	HCN4	Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
	TBX20	T-box transcription factor 20. (449 aa)
	ACTN2	Actinin alpha 2. (902 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTN2	ENSCHIP00000011080	ENSCHIP00000006208	Uncharacterized protein.	Actinin alpha 2.	0.501
ACTB	CAV1	ENSCHIP00000011080	ENSCHIP00000020742	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.830
ACTB	CDX2	ENSCHIP00000011080	ENSCHIP00000029734	Uncharacterized protein.	Caudal type homeobox 2.	0.520
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	CXCR4	ENSCHIP00000011080	ENSCHIP00000011766	Uncharacterized protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.759
ACTB	FGF10	ENSCHIP00000011080	ENSCHIP00000010028	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.589
ACTB	GATA6	ENSCHIP00000011080	ENSCHIP00000020060	Uncharacterized protein.	GATA binding protein 6.	0.481
ACTB	ISL1	ENSCHIP00000011080	ENSCHIP00000025978	Uncharacterized protein.	ISL LIM homeobox 1.	0.402
ACTB	NFATC1	ENSCHIP00000011080	ENSCHIP00000023403	Uncharacterized protein.	Nuclear factor of activated T cells 1.	0.708
ACTB	POLR2A	ENSCHIP00000011080	ENSCHIP00000033744	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.617
ACTB	SHH	ENSCHIP00000011080	ENSCHIP00000027767	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.702
ACTB	SOX1	ENSCHIP00000011080	ENSCHIP00000019659	Uncharacterized protein.	SRY-box transcription factor 1.	0.455
ACTB	SOX17	ENSCHIP00000011080	ENSCHIP00000023300	Uncharacterized protein.	SRY-box transcription factor 17.	0.531
ACTN2	ACTB	ENSCHIP00000006208	ENSCHIP00000011080	Actinin alpha 2.	Uncharacterized protein.	0.501
ACTN2	HAND2	ENSCHIP00000006208	ENSCHIP00000009629	Actinin alpha 2.	Heart and neural crest derivatives expressed 2.	0.494
ACTN2	HCN4	ENSCHIP00000006208	ENSCHIP00000008186	Actinin alpha 2.	Hyperpolarization activated cyclic nucleotide gated potassium channel 4.	0.503
ACTN2	NKX2-5	ENSCHIP00000006208	ENSCHIP00000017688	Actinin alpha 2.	NK2 homeobox 5.	0.811
ACTN2	RYR2	ENSCHIP00000006208	ENSCHIP00000033577	Actinin alpha 2.	Ryanodine receptor 2.	0.674
ACTN2	TBX5	ENSCHIP00000006208	ENSCHIP00000028388	Actinin alpha 2.	T-box transcription factor 5.	0.671
CAV1	ACTB	ENSCHIP00000020742	ENSCHIP00000011080	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.830