40 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCM4	DNA helicase; Belongs to the MCM family. (851 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1020 aa)
	ALB	Serum albumin. (608 aa)
	DNA2	DNA replication helicase/nuclease 2. (1062 aa)
	ENSCHIP00000022284	Annexin. (275 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (808 aa)
	SIN3A	SIN3 transcription regulator family member A. (1274 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	ANXA1	Annexin. (346 aa)
	ANXA5	Annexin. (334 aa)
	E2F7	E2F transcription factor 7. (911 aa)
	PDS5A	PDS5 cohesin associated factor A. (1337 aa)
	ANXA9	Annexin. (345 aa)
	LOC108634039	Annexin. (449 aa)
	ANXA4	Annexin. (320 aa)
	LOC102176495	Annexin. (331 aa)
	ANXA11	Annexin. (503 aa)
	ANXA7	Annexin. (485 aa)
	VCL	Vinculin. (1134 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
	ANXA2	Annexin. (339 aa)
	CD34	Uncharacterized protein. (384 aa)
	CDK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	CD4	CD4 molecule. (455 aa)
	SMC3	Structural maintenance of chromosomes protein. (1231 aa)
	ANXA3	Annexin. (323 aa)
	ACE	Angiotensin-converting enzyme. (1313 aa)
	ANXA13	Annexin. (371 aa)
	ENSCHIP00000009938	Annexin. (100 aa)
	SP1	Uncharacterized protein. (786 aa)
	ACTB	Uncharacterized protein. (375 aa)
	RAD9A	Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa)
	NFIC	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (506 aa)
	NUCKS1	Uncharacterized protein. (248 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ANXA6	Annexin. (689 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	WEE1	Wee1-like protein kinase. (645 aa)
	CDK2AP1	Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (115 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACTB	ENSCHIP00000009113	ENSCHIP00000011080	Angiotensin-converting enzyme.	Uncharacterized protein.	0.707
ACE	ALB	ENSCHIP00000009113	ENSCHIP00000020234	Angiotensin-converting enzyme.	Serum albumin.	0.794
ACE	CD4	ENSCHIP00000009113	ENSCHIP00000006662	Angiotensin-converting enzyme.	CD4 molecule.	0.518
ACTB	ACE	ENSCHIP00000011080	ENSCHIP00000009113	Uncharacterized protein.	Angiotensin-converting enzyme.	0.707
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	ANXA1	ENSCHIP00000011080	ENSCHIP00000023293	Uncharacterized protein.	Annexin.	0.799
ACTB	ANXA11	ENSCHIP00000011080	ENSCHIP00000000173	Uncharacterized protein.	Annexin.	0.767
ACTB	ANXA13	ENSCHIP00000011080	ENSCHIP00000009473	Uncharacterized protein.	Annexin.	0.768
ACTB	ANXA2	ENSCHIP00000011080	ENSCHIP00000002620	Uncharacterized protein.	Annexin.	0.870
ACTB	ANXA3	ENSCHIP00000011080	ENSCHIP00000008438	Uncharacterized protein.	Annexin.	0.768
ACTB	ANXA4	ENSCHIP00000011080	ENSCHIP00000033451	Uncharacterized protein.	Annexin.	0.769
ACTB	ANXA5	ENSCHIP00000011080	ENSCHIP00000024678	Uncharacterized protein.	Annexin.	0.867
ACTB	ANXA6	ENSCHIP00000011080	ENSCHIP00000016041	Uncharacterized protein.	Annexin.	0.768
ACTB	ANXA7	ENSCHIP00000011080	ENSCHIP00000000188	Uncharacterized protein.	Annexin.	0.767
ACTB	ANXA9	ENSCHIP00000011080	ENSCHIP00000028656	Uncharacterized protein.	Annexin.	0.768
ACTB	ATM	ENSCHIP00000011080	ENSCHIP00000016363	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.762
ACTB	CD34	ENSCHIP00000011080	ENSCHIP00000002645	Uncharacterized protein.	Uncharacterized protein.	0.812
ACTB	CD4	ENSCHIP00000011080	ENSCHIP00000006662	Uncharacterized protein.	CD4 molecule.	0.883
ACTB	CDK1	ENSCHIP00000011080	ENSCHIP00000000505	Uncharacterized protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.790
ACTB	CDK2	ENSCHIP00000011080	ENSCHIP00000003142	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.838