STRINGSTRING
LPIN3 LPIN3 MAPK14 MAPK14 PNLIPRP1 PNLIPRP1 SLC27A5 SLC27A5 PNLIP PNLIP FFAR2 FFAR2 LPIN2 LPIN2 FFAR1 FFAR1 PRP6 PRP6 INS INS GH1 GH1 CEBPA CEBPA AGPAT5 AGPAT5 PNLIPRP2 PNLIPRP2 FFAR4 FFAR4 GPIHBP1 GPIHBP1 LOC102170569 LOC102170569 LOC102184390 LOC102184390 LOC102190477 LOC102190477 LCAT LCAT AGPAT2 AGPAT2 NPC1L1 NPC1L1 LIPG LIPG LOC102178616 LOC102178616 LOC108638107 LOC108638107 IFNG IFNG SLC27A2 SLC27A2 PNLIPRP3 PNLIPRP3 HNF4A HNF4A STAR STAR CROT CROT CCK CCK AGPAT1 AGPAT1 FASN FASN LPIN1 LPIN1 IGF1 IGF1 ALB ALB AGPAT3 AGPAT3 CAV1 CAV1 LEP LEP ACSL5 ACSL5 MTOR MTOR GPAM GPAM LIPE LIPE GPAT4 GPAT4 VLDLR VLDLR PRP1 PRP1 APOE APOE FABP5 FABP5 AASDH AASDH ACSL1 ACSL1 LMF1 LMF1 LOC102180550 LOC102180550 LOC102171116 LOC102171116 INSIG1 INSIG1 LACC1 LACC1 ANGPTL4 ANGPTL4 SREBF1 SREBF1 CPT1C CPT1C GPAT3 GPAT3 MTTP MTTP LPL LPL SLC27A4 SLC27A4 FFAR3 FFAR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LPIN3Lipin 3. (851 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (416 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
PNLIPTriacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa)
FFAR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (329 aa)
LPIN2Lipin 2. (889 aa)
FFAR1Free fatty acid receptor 1. (301 aa)
PRP6Prolactin-related protein-6. (239 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (217 aa)
CEBPACCAAT enhancer binding protein alpha. (353 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (395 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (469 aa)
FFAR4Free fatty acid receptor 4. (378 aa)
GPIHBP1Uncharacterized protein. (92 aa)
LOC102170569Uncharacterized protein. (211 aa)
LOC102184390Uncharacterized protein. (287 aa)
LOC102190477Uncharacterized protein. (238 aa)
LCATLecithin-cholesterol acyltransferase. (440 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1333 aa)
LIPGLipase G, endothelial type. (563 aa)
LOC102178616Uncharacterized protein. (265 aa)
LOC108638107Uncharacterized protein. (238 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
PNLIPRP3Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (477 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (486 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
CROTCarnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (611 aa)
CCKCholecystokinin. (115 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (323 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
LPIN1Lipin 1. (913 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
ALBSerum albumin. (608 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (844 aa)
LIPELipase E, hormone sensitive type. (756 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
VLDLRVery low density lipoprotein receptor. (873 aa)
PRP1Prolactin-related protein-1. (238 aa)
APOEApolipoprotein E. (326 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
AASDHAminoadipate-semialdehyde dehydrogenase. (1106 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (719 aa)
LMF1Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (569 aa)
LOC102180550Uncharacterized protein. (237 aa)
LOC102171116Uncharacterized protein. (226 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (278 aa)
LACC1Uncharacterized protein. (426 aa)
ANGPTL4Angiopoietin like 4. (413 aa)
SREBF1Uncharacterized protein. (68 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (796 aa)
GPAT3Glycerol-3-phosphate acyltransferase 3. (439 aa)
MTTPMicrosomal triglyceride transfer protein. (908 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (487 aa)
SLC27A4Solute carrier family 27 member 4. (643 aa)
FFAR3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (365 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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