25 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BGN	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
	SERPINH1	Serpin family H member 1; Belongs to the serpin family. (418 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	COL10A1	Collagen type X alpha 1 chain. (674 aa)
	TIMP1	NTR domain-containing protein. (207 aa)
	LGALS3	Galectin. (260 aa)
	COL5A2	Collagen type V alpha 2 chain. (1252 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	RUNX2	RUNX family transcription factor 2. (585 aa)
	PXDN	Peroxidasin. (1525 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (745 aa)
	THBS2	Thrombospondin 2. (1181 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
	MMP9	Uncharacterized protein. (709 aa)
	COL6A3	Collagen type VI alpha 3 chain. (3111 aa)
	NID2	Nidogen 2. (1305 aa)
	COL12A1	Collagen type XII alpha 1 chain. (3046 aa)
	MMP13	Matrix metallopeptidase 13. (472 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	FBN1	Fibrillin 1. (2860 aa)
	BMP1	Metalloendopeptidase. (988 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (435 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	BGN	ENSCHIP00000011080	ENSCHIP00000003173	Uncharacterized protein.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.436
ACTB	COL10A1	ENSCHIP00000011080	ENSCHIP00000004232	Uncharacterized protein.	Collagen type X alpha 1 chain.	0.480
ACTB	COL1A1	ENSCHIP00000011080	ENSCHIP00000023918	Uncharacterized protein.	Collagen type I alpha 1 chain.	0.776
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	CXCR4	ENSCHIP00000011080	ENSCHIP00000011766	Uncharacterized protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.759
ACTB	LGALS3	ENSCHIP00000011080	ENSCHIP00000008370	Uncharacterized protein.	Galectin.	0.653
ACTB	MMP13	ENSCHIP00000011080	ENSCHIP00000023527	Uncharacterized protein.	Matrix metallopeptidase 13.	0.722
ACTB	MMP9	ENSCHIP00000011080	ENSCHIP00000016938	Uncharacterized protein.	Uncharacterized protein.	0.881
ACTB	PTH	ENSCHIP00000011080	ENSCHIP00000003441	Uncharacterized protein.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.515
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	RUNX1	ENSCHIP00000011080	ENSCHIP00000016603	Uncharacterized protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.591
ACTB	RUNX2	ENSCHIP00000011080	ENSCHIP00000015454	Uncharacterized protein.	RUNX family transcription factor 2.	0.834
ACTB	RUNX3	ENSCHIP00000011080	ENSCHIP00000029126	Uncharacterized protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.512
ACTB	TIMP1	ENSCHIP00000011080	ENSCHIP00000006216	Uncharacterized protein.	NTR domain-containing protein.	0.567
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
BGN	ACTB	ENSCHIP00000003173	ENSCHIP00000011080	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Uncharacterized protein.	0.436
BGN	BMP1	ENSCHIP00000003173	ENSCHIP00000027161	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Metalloendopeptidase.	0.643
BGN	COL10A1	ENSCHIP00000003173	ENSCHIP00000004232	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type X alpha 1 chain.	0.531
BGN	COL12A1	ENSCHIP00000003173	ENSCHIP00000020533	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type XII alpha 1 chain.	0.634
BGN	COL1A1	ENSCHIP00000003173	ENSCHIP00000023918	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen type I alpha 1 chain.	0.910