STRINGSTRING
NONO NONO BRCA1 BRCA1 HNRNPA1 HNRNPA1 TOP1 TOP1 SFPQ SFPQ GAPDH GAPDH MSH2 MSH2 LOC102189503 LOC102189503 HNRNPL HNRNPL LOC106502806 LOC106502806 SLC46A1 SLC46A1 CD48 CD48 ALB ALB LOC102168547 LOC102168547 DHX9 DHX9 HMOX1 HMOX1 BRIP1 BRIP1 RAD51C RAD51C WRN WRN PIF1 PIF1 HNRNPK HNRNPK LIF LIF MSH6 MSH6 RTEL1 RTEL1 EEF2 EEF2 TOP2A TOP2A SLC48A1 SLC48A1 LOC102169981 LOC102169981 LOC102171353 LOC102171353 NCL NCL LOC108633916 LOC108633916 LOC106503499 LOC106503499 BLM BLM LOC102180554 LOC102180554 B2M B2M LOC108634231 LOC108634231 H3-4 H3-4 LOC108636012 LOC108636012 E2F2 E2F2 LOC102182848 LOC102182848 LOC108633554 LOC108633554 LOC102185882 LOC102185882 LOC102191748 LOC102191748
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NONONon-POU domain containing octamer binding. (470 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
HNRNPA1Uncharacterized protein. (320 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
SFPQSplicing factor proline and glutamine rich. (711 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
HNRNPLUncharacterized protein. (616 aa)
LOC106502806Uncharacterized protein. (616 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
CD48Ig-like domain-containing protein. (236 aa)
ALBSerum albumin. (608 aa)
LOC102168547Beta-2-microglobulin. (124 aa)
DHX9DExH-box helicase 9. (1271 aa)
HMOX1Heme oxygenase 1. (288 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
RAD51CRAD51 paralog C. (371 aa)
WRNWRN RecQ like helicase. (1405 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
HNRNPKUncharacterized protein. (454 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
EEF2Tr-type G domain-containing protein. (858 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa)
SLC48A1Solute carrier family 48 member 1. (146 aa)
LOC102169981Histone domain-containing protein. (136 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
NCLUncharacterized protein. (667 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503499Histone H3; Belongs to the histone H3 family. (136 aa)
BLMBLM RecQ like helicase. (1429 aa)
LOC102180554Histone H3; Belongs to the histone H3 family. (136 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
LOC108634231Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
E2F2E2F transcription factor 2. (437 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633554Histone domain-containing protein. (136 aa)
LOC102185882Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102191748Histone domain-containing protein. (136 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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