34 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (129 aa)
	IL37	Interleukin-1. (265 aa)
	CD38	Uncharacterized protein. (277 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	IL1RN	Interleukin-1. (183 aa)
	CD4	CD4 molecule. (455 aa)
	CXCL5	C-X-C motif chemokine. (119 aa)
	CCL24	C-C motif chemokine ligand 24. (116 aa)
	IL36B	Interleukin-1. (158 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	CCL11	C-C motif chemokine. (97 aa)
	ACTB	Uncharacterized protein. (375 aa)
	LOC102175746	C-type lectin domain-containing protein. (285 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	FOXP3	Forkhead box P3. (463 aa)
	PXDN	Peroxidasin. (1525 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	IL10	Interleukin 10. (177 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
	IL13	Interleukin 13. (131 aa)
	IL33	Interleukin 33. (274 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	IL36A	Interleukin-1. (176 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL36RN	Interleukin-1. (161 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CCL2	C-C motif chemokine. (98 aa)
	LOC102182683	C-X-C motif chemokine. (109 aa)
	IL36G	Interleukin-1. (171 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
	IL1F10	Interleukin-1. (152 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (877 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CCL11	ENSCHIP00000011080	ENSCHIP00000010436	Uncharacterized protein.	C-C motif chemokine.	0.437
ACTB	CCL2	ENSCHIP00000011080	ENSCHIP00000027804	Uncharacterized protein.	C-C motif chemokine.	0.764
ACTB	CD38	ENSCHIP00000011080	ENSCHIP00000001838	Uncharacterized protein.	Uncharacterized protein.	0.544
ACTB	CD4	ENSCHIP00000011080	ENSCHIP00000006662	Uncharacterized protein.	CD4 molecule.	0.883
ACTB	CXCL5	ENSCHIP00000011080	ENSCHIP00000006680	Uncharacterized protein.	C-X-C motif chemokine.	0.442
ACTB	CXCR4	ENSCHIP00000011080	ENSCHIP00000011766	Uncharacterized protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.759
ACTB	FOXP3	ENSCHIP00000011080	ENSCHIP00000012575	Uncharacterized protein.	Forkhead box P3.	0.760
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	IFNG	ENSCHIP00000011080	ENSCHIP00000016152	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.875
ACTB	IL10	ENSCHIP00000011080	ENSCHIP00000016929	Uncharacterized protein.	Interleukin 10.	0.865
ACTB	IL13	ENSCHIP00000011080	ENSCHIP00000021940	Uncharacterized protein.	Interleukin 13.	0.750
ACTB	IL18	ENSCHIP00000011080	ENSCHIP00000023420	Uncharacterized protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.780
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	IL1F10	ENSCHIP00000011080	ENSCHIP00000032446	Uncharacterized protein.	Interleukin-1.	0.657
ACTB	IL1RN	ENSCHIP00000011080	ENSCHIP00000005667	Uncharacterized protein.	Interleukin-1.	0.658
ACTB	IL2	ENSCHIP00000011080	ENSCHIP00000029633	Uncharacterized protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family.	0.756
ACTB	IL33	ENSCHIP00000011080	ENSCHIP00000022262	Uncharacterized protein.	Interleukin 33.	0.612
ACTB	IL36A	ENSCHIP00000011080	ENSCHIP00000023251	Uncharacterized protein.	Interleukin-1.	0.659
ACTB	IL36B	ENSCHIP00000011080	ENSCHIP00000007380	Uncharacterized protein.	Interleukin-1.	0.657
ACTB	IL36G	ENSCHIP00000011080	ENSCHIP00000029171	Uncharacterized protein.	Interleukin-1.	0.657