STRINGSTRING
MFN2 MFN2 MAP1LC3B MAP1LC3B ATG16L1 ATG16L1 PIK3R4 PIK3R4 PINK1 PINK1 WIPI2 WIPI2 CALCOCO2 CALCOCO2 ATG12 ATG12 ATG9A ATG9A UBB UBB GAPDH GAPDH SAR1B SAR1B FIS1 FIS1 BECN1 BECN1 ATG2B ATG2B C16orf70 C16orf70 MTOR MTOR ATG5 ATG5 ULK1 ULK1 ATG7 ATG7 WDR45B WDR45B PEF1 PEF1 WIPI1 WIPI1 RB1CC1 RB1CC1 USP4 USP4 ATG101 ATG101 ATG2A ATG2A BCAS3 BCAS3 ATG14 ATG14 RAB1B RAB1B PIK3C3 PIK3C3 STX17 STX17 WHAMM WHAMM ATG13 ATG13 WDR45 WDR45 RAB1A RAB1A ACTA1 ACTA1 LOC102181016 LOC102181016 ZFYVE1 ZFYVE1 JMY JMY RAB24 RAB24 GAPDHS GAPDHS LOC102176799 LOC102176799 TOMM20 TOMM20 COX2 COX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
MAP1LC3BUncharacterized protein. (143 aa)
ATG16L1Autophagy related 16 like 1. (607 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1310 aa)
PINK1PTEN induced kinase 1. (587 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (436 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (448 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
UBBUbiquitin B. (323 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
BECN1Uncharacterized protein. (448 aa)
ATG2BAutophagy related 2B. (2056 aa)
C16orf70Chromosome 16 open reading frame 70. (422 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1055 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (722 aa)
WDR45BWD repeat domain 45B. (344 aa)
PEF1Penta-EF-hand domain containing 1. (287 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (447 aa)
RB1CC1RB1 inducible coiled-coil 1. (1589 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (963 aa)
ATG101Autophagy related 101. (218 aa)
ATG2AAutophagy related 2A. (1927 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (824 aa)
ATG14Autophagy related 14. (492 aa)
RAB1BRAB1B, member RAS oncogene family. (201 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (301 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (806 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (517 aa)
WDR45Uncharacterized protein. (360 aa)
RAB1AUncharacterized protein. (206 aa)
ACTA1Uncharacterized protein; Belongs to the actin family. (223 aa)
LOC102181016Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (789 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (982 aa)
RAB24RAB24, member RAS oncogene family. (203 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (385 aa)
LOC102176799Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TOMM20Translocase of outer mitochondrial membrane 20. (145 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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