25 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	LOC102181016	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
	ACTB	Uncharacterized protein. (375 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	HMOX1	Heme oxygenase 1. (288 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
	IL10	Interleukin 10. (177 aa)
	ALB	Serum albumin. (608 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
	ENSCHIP00000023849	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (177 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	GPX4	Uncharacterized protein. (190 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	LOC102168954	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
	LOC102176799	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (385 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	ENSCHIP00000023849	ENSCHIP00000011080	ENSCHIP00000023849	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.718
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GAPDHS	ENSCHIP00000011080	ENSCHIP00000005676	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.911
ACTB	GPX4	ENSCHIP00000011080	ENSCHIP00000028055	Uncharacterized protein.	Uncharacterized protein.	0.718
ACTB	GPX6	ENSCHIP00000011080	ENSCHIP00000020908	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.704
ACTB	GPX7	ENSCHIP00000011080	ENSCHIP00000029981	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	GPX8	ENSCHIP00000011080	ENSCHIP00000026386	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	GSR	ENSCHIP00000011080	ENSCHIP00000016690	Uncharacterized protein.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.593
ACTB	HMOX1	ENSCHIP00000011080	ENSCHIP00000016460	Uncharacterized protein.	Heme oxygenase 1.	0.845
ACTB	IFNG	ENSCHIP00000011080	ENSCHIP00000016152	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.875
ACTB	IL10	ENSCHIP00000011080	ENSCHIP00000016929	Uncharacterized protein.	Interleukin 10.	0.865
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	IL6	ENSCHIP00000011080	ENSCHIP00000009414	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.919
ACTB	JUN	ENSCHIP00000011080	ENSCHIP00000001903	Uncharacterized protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.681
ACTB	KEAP1	ENSCHIP00000011080	ENSCHIP00000009131	Uncharacterized protein.	Kelch like ECH associated protein 1.	0.780
ACTB	LOC102168954	ENSCHIP00000011080	ENSCHIP00000004343	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.716
ACTB	LOC102176799	ENSCHIP00000011080	ENSCHIP00000004827	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.937