STRINGSTRING
TYMS TYMS CD40LG CD40LG CDK1 CDK1 NDC80 NDC80 TIPIN TIPIN KIF23 KIF23 ANP32E ANP32E CD38 CD38 CD5 CD5 NUSAP1 NUSAP1 RFC2 RFC2 FEN1 FEN1 CDC6 CDC6 NEK2 NEK2 RRM2 RRM2 LOC108633924 LOC108633924 TTK TTK CD4 CD4 CENPA CENPA TMPO TMPO MCM5 MCM5 BUB1 BUB1 WDR76 WDR76 IL6 IL6 IL6R IL6R KIF20B KIF20B CENPF CENPF CKS1B CKS1B TOP2A TOP2A EXO1 EXO1 CDCA3 CDCA3 TACC3 TACC3 BIRC5 BIRC5 LBR LBR CTCF CTCF DSCC1 DSCC1 NASP NASP CCNB2 CCNB2 CDC45 CDC45 GAS2L3 GAS2L3 NCAPD2 NCAPD2 PCNA PCNA USP1 USP1 UBE2C UBE2C CHAF1B CHAF1B GINS2 GINS2 POLA1 POLA1 ANLN ANLN DLGAP5 DLGAP5 CASP8AP2 CASP8AP2 CENPE CENPE MCM4 MCM4 KIF11 KIF11 CKAP5 CKAP5 UHRF1 UHRF1 CDCA2 CDCA2 RRM1 RRM1 SMC4 SMC4 UBR7 UBR7 SLBP SLBP HELLS HELLS PIMREG PIMREG GMNN GMNN BCR BCR HJURP HJURP PSRC1 PSRC1 CD27 CD27 NUF2 NUF2 ATAD2 ATAD2 KIF2C KIF2C MSH2 MSH2 TUBB4B TUBB4B CKS2 CKS2 FURIN FURIN CCNE2 CCNE2 AURKB AURKB CKAP2 CKAP2 CLSPN CLSPN E2F8 E2F8 CD19 CD19 AURKA AURKA CDC25C CDC25C ECT2 ECT2 G2E3 G2E3 CBX5 CBX5 RANGAP1 RANGAP1 HMMR HMMR CDCA8 CDCA8 RAD51 RAD51 PRIM1 PRIM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TYMSThymidylate synthetase. (355 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (966 aa)
ANP32EAcidic nuclear phosphoprotein 32 family member E. (231 aa)
CD38Uncharacterized protein. (277 aa)
CD5CD5 molecule. (505 aa)
NUSAP1Uncharacterized protein. (431 aa)
RFC2Replication factor C subunit 2. (352 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa)
NEK2NIMA related kinase 2. (445 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (389 aa)
LOC108633924Histone domain-containing protein. (138 aa)
TTKTTK protein kinase. (852 aa)
CD4CD4 molecule. (455 aa)
CENPACentromere protein A. (138 aa)
TMPOThymopoietin. (689 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1090 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (626 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
IL6RInterleukin 6 receptor. (441 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1761 aa)
CENPFCentromere protein F. (3055 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa)
EXO1Exonuclease 1. (835 aa)
CDCA3Cell division cycle associated 3. (265 aa)
TACC3TACC_C domain-containing protein. (743 aa)
BIRC5Uncharacterized protein. (142 aa)
LBRLamin B receptor. (647 aa)
CTCFCCCTC-binding factor. (727 aa)
DSCC1Uncharacterized protein. (388 aa)
NASPNuclear autoantigenic sperm protein. (770 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
CDC45Cell division cycle 45. (524 aa)
GAS2L3Growth arrest specific 2 like 3. (693 aa)
NCAPD2Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1396 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (782 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
CHAF1BChromatin assembly factor 1 subunit B. (567 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
POLA1DNA polymerase. (1468 aa)
ANLNAnillin actin binding protein. (1148 aa)
DLGAP5DLG associated protein 5. (843 aa)
CASP8AP2Caspase 8 associated protein 2. (1971 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2431 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
KIF11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1055 aa)
CKAP5Cytoskeleton associated protein 5. (2040 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (786 aa)
CDCA2Cell division cycle associated 2. (1008 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
UBR7UBR-type domain-containing protein. (425 aa)
SLBPStem-loop binding protein. (275 aa)
HELLSHelicase, lymphoid specific. (824 aa)
PIMREGPICALM interacting mitotic regulator. (239 aa)
GMNNGeminin DNA replication inhibitor. (186 aa)
BCRBCR activator of RhoGEF and GTPase. (1130 aa)
HJURPHolliday junction recognition protein. (694 aa)
PSRC1Proline and serine rich coiled-coil 1. (326 aa)
CD27CD27 molecule. (270 aa)
NUF2NUF2 component of NDC80 kinetochore complex. (465 aa)
ATAD2ATPase family AAA domain containing 2. (1385 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (721 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CKAP2Cytoskeleton associated protein 2. (682 aa)
CLSPNClaspin. (1339 aa)
E2F8E2F transcription factor 8. (866 aa)
CD19CD19 molecule. (561 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
CDC25CCell division cycle 25C. (452 aa)
ECT2Epithelial cell transforming 2. (913 aa)
G2E3G2/M-phase specific E3 ubiquitin protein ligase. (703 aa)
CBX5Chromobox 5. (191 aa)
RANGAP1Ran GTPase activating protein 1. (585 aa)
HMMRHyaluronan mediated motility receptor. (715 aa)
CDCA8Cell division cycle associated 8. (280 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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