21 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TOM1	Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (510 aa)
	STAT6	Signal transducer and activator of transcription. (841 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	JAK1	Tyrosine-protein kinase. (1159 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	ACTB	Uncharacterized protein. (375 aa)
	PXDN	Peroxidasin. (1525 aa)
	IL10	Interleukin 10. (177 aa)
	IRF4	Interferon regulatory factor 4. (450 aa)
	ALB	Serum albumin. (608 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CD68	CD68 molecule. (335 aa)
	LEPR	Leptin receptor. (1166 aa)
	GOT1	Aspartate aminotransferase. (413 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CCR7	ENSCHIP00000011080	ENSCHIP00000020512	Uncharacterized protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.582
ACTB	CD68	ENSCHIP00000011080	ENSCHIP00000027336	Uncharacterized protein.	CD68 molecule.	0.791
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GOT1	ENSCHIP00000011080	ENSCHIP00000029101	Uncharacterized protein.	Aspartate aminotransferase.	0.779
ACTB	GOT2	ENSCHIP00000011080	ENSCHIP00000010968	Uncharacterized protein.	Aspartate aminotransferase.	0.779
ACTB	IL10	ENSCHIP00000011080	ENSCHIP00000016929	Uncharacterized protein.	Interleukin 10.	0.865
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	IRF4	ENSCHIP00000011080	ENSCHIP00000017187	Uncharacterized protein.	Interferon regulatory factor 4.	0.583
ACTB	JAK1	ENSCHIP00000011080	ENSCHIP00000010087	Uncharacterized protein.	Tyrosine-protein kinase.	0.746
ACTB	JAK2	ENSCHIP00000011080	ENSCHIP00000001875	Uncharacterized protein.	Tyrosine-protein kinase.	0.816
ACTB	JUN	ENSCHIP00000011080	ENSCHIP00000001903	Uncharacterized protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.681
ACTB	LEPR	ENSCHIP00000011080	ENSCHIP00000027406	Uncharacterized protein.	Leptin receptor.	0.576
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	STAT1	ENSCHIP00000011080	ENSCHIP00000005767	Uncharacterized protein.	Signal transducer and activator of transcription.	0.838
ACTB	STAT3	ENSCHIP00000011080	ENSCHIP00000022282	Uncharacterized protein.	Signal transducer and activator of transcription.	0.882
ACTB	STAT6	ENSCHIP00000011080	ENSCHIP00000031225	Uncharacterized protein.	Signal transducer and activator of transcription.	0.725
ACTB	TGFB1	ENSCHIP00000011080	ENSCHIP00000008885	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.831
ACTB	TNF	ENSCHIP00000011080	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.886
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961