(24 nodes) (2021) The role of PKM2 nuclear translocation in the constant activation of the NF-kappaB signaling pathway in cancer-associated fibroblasts. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	MMP9	Uncharacterized protein. (709 aa)
	HK1	Hexokinase 1. (945 aa)
	CD34	Uncharacterized protein. (384 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	HKDC1	Hexokinase domain containing 1. (918 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	HK2	Hexokinase 2. (917 aa)
	ACTB	Uncharacterized protein. (375 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	PXDN	Peroxidasin. (1525 aa)
	LOC102190507	Uncharacterized protein. (139 aa)
	ALB	Serum albumin. (608 aa)
	TCF4	Transcription factor 4. (647 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	CD63	Tetraspanin. (237 aa)
	POU5F1	POU domain protein. (360 aa)
	CD44	CD44 molecule (Indian blood group). (715 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	HK3	Hexokinase 3. (924 aa)
	PFKP	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
	CTNNB1	Catenin beta 1. (781 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CD34	ENSCHIP00000011080	ENSCHIP00000002645	Uncharacterized protein.	Uncharacterized protein.	0.812
ACTB	CD44	ENSCHIP00000011080	ENSCHIP00000024231	Uncharacterized protein.	CD44 molecule (Indian blood group).	0.835
ACTB	CD63	ENSCHIP00000011080	ENSCHIP00000023741	Uncharacterized protein.	Tetraspanin.	0.795
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	EGFR	ENSCHIP00000011080	ENSCHIP00000022759	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.891
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	HK1	ENSCHIP00000011080	ENSCHIP00000000719	Uncharacterized protein.	Hexokinase 1.	0.685
ACTB	HK2	ENSCHIP00000011080	ENSCHIP00000009707	Uncharacterized protein.	Hexokinase 2.	0.728
ACTB	HK3	ENSCHIP00000011080	ENSCHIP00000029968	Uncharacterized protein.	Hexokinase 3.	0.585
ACTB	HKDC1	ENSCHIP00000011080	ENSCHIP00000007027	Uncharacterized protein.	Hexokinase domain containing 1.	0.584
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	IL6	ENSCHIP00000011080	ENSCHIP00000009414	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.919
ACTB	LMNB1	ENSCHIP00000011080	ENSCHIP00000011489	Uncharacterized protein.	Lamin B1; Belongs to the intermediate filament family.	0.904
ACTB	LOC102190507	ENSCHIP00000011080	ENSCHIP00000018311	Uncharacterized protein.	Uncharacterized protein.	0.658
ACTB	MMP9	ENSCHIP00000011080	ENSCHIP00000016938	Uncharacterized protein.	Uncharacterized protein.	0.881
ACTB	PFKP	ENSCHIP00000011080	ENSCHIP00000030216	Uncharacterized protein.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.663
ACTB	PKM	ENSCHIP00000011080	ENSCHIP00000015417	Uncharacterized protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.744
ACTB	POU5F1	ENSCHIP00000011080	ENSCHIP00000023987	Uncharacterized protein.	POU domain protein.	0.794