12 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	POLA2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CHEK2	Checkpoint kinase 2. (534 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
	CDT1	Chromatin licensing and DNA replication factor 1. (637 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	CDC45	Cell division cycle 45. (524 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ADSL	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (490 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CHEK2	ENSCHIP00000011490	ENSCHIP00000027824	Caspase 3; Belongs to the peptidase C14A family.	Checkpoint kinase 2.	0.432
CASP3	GAPDH	ENSCHIP00000011490	ENSCHIP00000025974	Caspase 3; Belongs to the peptidase C14A family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.943
CASP3	KEAP1	ENSCHIP00000011490	ENSCHIP00000009131	Caspase 3; Belongs to the peptidase C14A family.	Kelch like ECH associated protein 1.	0.730
CASP3	MTOR	ENSCHIP00000011490	ENSCHIP00000021872	Caspase 3; Belongs to the peptidase C14A family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.696
CDC45	CDT1	ENSCHIP00000013791	ENSCHIP00000009696	Cell division cycle 45.	Chromatin licensing and DNA replication factor 1.	0.985
CDC45	CHEK2	ENSCHIP00000013791	ENSCHIP00000027824	Cell division cycle 45.	Checkpoint kinase 2.	0.696
CDC45	PCNA	ENSCHIP00000013791	ENSCHIP00000015091	Cell division cycle 45.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.487
CDC45	POLA2	ENSCHIP00000013791	ENSCHIP00000024367	Cell division cycle 45.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.928
CDC45	POLD2	ENSCHIP00000013791	ENSCHIP00000005641	Cell division cycle 45.	DNA polymerase delta 2, accessory subunit.	0.716
CDC45	POLE2	ENSCHIP00000013791	ENSCHIP00000028310	Cell division cycle 45.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.996
CDT1	CDC45	ENSCHIP00000009696	ENSCHIP00000013791	Chromatin licensing and DNA replication factor 1.	Cell division cycle 45.	0.985
CDT1	CHEK2	ENSCHIP00000009696	ENSCHIP00000027824	Chromatin licensing and DNA replication factor 1.	Checkpoint kinase 2.	0.474
CDT1	PCNA	ENSCHIP00000009696	ENSCHIP00000015091	Chromatin licensing and DNA replication factor 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.970
CDT1	POLA2	ENSCHIP00000009696	ENSCHIP00000024367	Chromatin licensing and DNA replication factor 1.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.735
CDT1	POLD2	ENSCHIP00000009696	ENSCHIP00000005641	Chromatin licensing and DNA replication factor 1.	DNA polymerase delta 2, accessory subunit.	0.520
CDT1	POLE2	ENSCHIP00000009696	ENSCHIP00000028310	Chromatin licensing and DNA replication factor 1.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.725
CHEK2	CASP3	ENSCHIP00000027824	ENSCHIP00000011490	Checkpoint kinase 2.	Caspase 3; Belongs to the peptidase C14A family.	0.432
CHEK2	CDC45	ENSCHIP00000027824	ENSCHIP00000013791	Checkpoint kinase 2.	Cell division cycle 45.	0.696
CHEK2	CDT1	ENSCHIP00000027824	ENSCHIP00000009696	Checkpoint kinase 2.	Chromatin licensing and DNA replication factor 1.	0.474
CHEK2	PCNA	ENSCHIP00000027824	ENSCHIP00000015091	Checkpoint kinase 2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.502