STRINGSTRING
TLR2 TLR2 CSF1 CSF1 NQO1 NQO1 FRK FRK NFKB1 NFKB1 FYN FYN KEAP1 KEAP1 IL6 IL6 CYBB CYBB NOS3 NOS3 LBR LBR LCK LCK GLB1 GLB1 ATF4 ATF4 PRKCD PRKCD FGR FGR TLR3 TLR3 IFNG IFNG HMOX1 HMOX1 MMP9 MMP9 ALB ALB HCK HCK GLB1L3 GLB1L3 LMNA LMNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
FRKTyrosine-protein kinase. (515 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
FYNTyrosine-protein kinase. (537 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
LBRLamin B receptor. (647 aa)
LCKTyrosine-protein kinase. (509 aa)
GLB1Beta-galactosidase. (646 aa)
ATF4Activating transcription factor 4. (352 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
FGRTyrosine-protein kinase. (527 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
HMOX1Heme oxygenase 1. (288 aa)
MMP9Uncharacterized protein. (709 aa)
ALBSerum albumin. (608 aa)
HCKTyrosine-protein kinase. (528 aa)
GLB1L3Beta-galactosidase. (664 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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