STRINGSTRING
H2BC12 H2BC12 TGFB3 TGFB3 FLT3 FLT3 BGN BGN RSC1A1 RSC1A1 CREB3L1 CREB3L1 RAPGEF3 RAPGEF3 LAMA5 LAMA5 IRF7 IRF7 CASP7 CASP7 TGFB1 TGFB1 IL6 IL6 COL5A2 COL5A2 CDK20 CDK20 ACTB ACTB PIK3C3 PIK3C3 CD163 CD163 PDGFC PDGFC CD86 CD86 THBS2 THBS2 CCL5 CCL5 IL10 IL10 THBS1 THBS1 DLGAP5 DLGAP5 ERMARD ERMARD CCNA2 CCNA2 FAT1 FAT1 TIAM1 TIAM1 FBLN2 FBLN2 COL6A3 COL6A3 ALB ALB IL4 IL4 COL12A1 COL12A1 SRSF7 SRSF7 TRAF1 TRAF1 FUNDC2 FUNDC2 IRF1 IRF1 STAT3 STAT3 ADORA2A ADORA2A IRF5 IRF5 COL1A1 COL1A1 TLN2 TLN2 VAV2 VAV2 ARG1 ARG1 COL4A1 COL4A1 KIT KIT TIMP3 TIMP3 TGFB2 TGFB2 ATP6V0C ATP6V0C CD68 CD68 PTGS2 PTGS2 CCL2 CCL2 CCNE1 CCNE1 PDGFRB PDGFRB CCN2 CCN2 CCND2 CCND2 LYVE1 LYVE1 COL1A2 COL1A2 LAMB1 LAMB1 COL4A2 COL4A2 CSF1R CSF1R BRCA1 BRCA1 CSF1 CSF1 CSF2 CSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2BC12Histone H2B; Belongs to the histone H2B family. (126 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (992 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
RSC1A1Regulator of solute carriers 1. (617 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (581 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (924 aa)
LAMA5Laminin subunit alpha 5. (2263 aa)
IRF7Interferon regulatory factor 7. (480 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
CDK20Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (346 aa)
ACTBUncharacterized protein. (375 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
CD163CD163 molecule. (1114 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
CD86Ig-like domain-containing protein. (289 aa)
THBS2Thrombospondin 2. (1181 aa)
CCL5C-C motif chemokine. (91 aa)
IL10Interleukin 10. (177 aa)
THBS1Thrombospondin 1. (1218 aa)
DLGAP5DLG associated protein 5. (843 aa)
ERMARDER membrane associated RNA degradation. (678 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
FAT1FAT atypical cadherin 1. (4643 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
FBLN2Uncharacterized protein. (458 aa)
COL6A3Collagen type VI alpha 3 chain. (3111 aa)
ALBSerum albumin. (608 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
COL12A1Collagen type XII alpha 1 chain. (3046 aa)
SRSF7Serine and arginine rich splicing factor 7. (238 aa)
TRAF1TNF receptor-associated factor. (410 aa)
FUNDC2Uncharacterized protein. (95 aa)
IRF1Interferon regulatory factor. (322 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (384 aa)
IRF5Interferon regulatory factor 5. (501 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
TLN2Talin 2. (2542 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
ARG1Arginase. (322 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
TIMP3Tissue inhibitor of metalloproteinase 3 protein. (211 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
CD68CD68 molecule. (335 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CCL2C-C motif chemokine. (98 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
CCN2Cellular communication network factor 2. (349 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (322 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
LAMB1Laminin subunit beta 1. (1842 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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