(10 nodes) (2021) Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. network (Capra hircus)

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Your Input:
	CTNNB1	Catenin beta 1. (781 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	PARP2	Poly [ADP-ribose] polymerase. (533 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1166 aa)
	AXIN2	Axin 2. (844 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ACTB	Uncharacterized protein. (375 aa)
	AXIN1	Axin 1. (867 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AXIN1	ENSCHIP00000011080	ENSCHIP00000006499	Uncharacterized protein.	Axin 1.	0.450
ACTB	AXIN2	ENSCHIP00000011080	ENSCHIP00000022676	Uncharacterized protein.	Axin 2.	0.666
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	SMAD3	ENSCHIP00000011080	ENSCHIP00000011729	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.847
ACTB	TNKS2	ENSCHIP00000011080	ENSCHIP00000023936	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.402
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
AXIN1	ACTB	ENSCHIP00000006499	ENSCHIP00000011080	Axin 1.	Uncharacterized protein.	0.450
AXIN1	AXIN2	ENSCHIP00000006499	ENSCHIP00000022676	Axin 1.	Axin 2.	0.984
AXIN1	CTNNB1	ENSCHIP00000006499	ENSCHIP00000031016	Axin 1.	Catenin beta 1.	0.999
AXIN1	GAPDH	ENSCHIP00000006499	ENSCHIP00000025974	Axin 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.446
AXIN1	PARP2	ENSCHIP00000006499	ENSCHIP00000029449	Axin 1.	Poly [ADP-ribose] polymerase.	0.404
AXIN1	SMAD3	ENSCHIP00000006499	ENSCHIP00000011729	Axin 1.	Mothers against decapentaplegic homolog.	0.409
AXIN1	TNKS	ENSCHIP00000006499	ENSCHIP00000004017	Axin 1.	Poly [ADP-ribose] polymerase.	0.978
AXIN1	TNKS2	ENSCHIP00000006499	ENSCHIP00000023936	Axin 1.	Poly [ADP-ribose] polymerase.	0.958
AXIN1	TP53	ENSCHIP00000006499	ENSCHIP00000030141	Axin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.699
AXIN2	ACTB	ENSCHIP00000022676	ENSCHIP00000011080	Axin 2.	Uncharacterized protein.	0.666
AXIN2	AXIN1	ENSCHIP00000022676	ENSCHIP00000006499	Axin 2.	Axin 1.	0.984
AXIN2	CTNNB1	ENSCHIP00000022676	ENSCHIP00000031016	Axin 2.	Catenin beta 1.	0.998
AXIN2	GAPDH	ENSCHIP00000022676	ENSCHIP00000025974	Axin 2.	Glyceraldehyde-3-phosphate dehydrogenase.	0.731