STRINGSTRING
SLC1A3 SLC1A3 ANLN ANLN PTPRZ1 PTPRZ1 MCM6 MCM6 DLGAP5 DLGAP5 CASP8AP2 CASP8AP2 CENPE CENPE PRIM1 PRIM1 CDCA7 CDCA7 DLX2 DLX2 CDC25C CDC25C AURKA AURKA FABP7 FABP7 IGF1R IGF1R GFAP GFAP E2F8 E2F8 CLSPN CLSPN NTRK2 NTRK2 SLC47A1 SLC47A1 CKAP2 CKAP2 AURKB AURKB CCNE2 CCNE2 CKS2 CKS2 TUBB4B TUBB4B KIF2C KIF2C ATAD2 ATAD2 NUF2 NUF2 SOX9 SOX9 PSRC1 PSRC1 NKG7 NKG7 VIM VIM CDC20 CDC20 OLIG1 OLIG1 GMNN GMNN PIMREG PIMREG HELLS HELLS SLBP SLBP UBR7 UBR7 IGF1 IGF1 SMC4 SMC4 RRM1 RRM1 CDCA2 CDCA2 UHRF1 UHRF1 CKAP5 CKAP5 KIF11 KIF11 SCN7A SCN7A TYMS TYMS NDC80 NDC80 TIPIN TIPIN KIF23 KIF23 ANP32E ANP32E GJA1 GJA1 PDGFRA PDGFRA OLIG2 OLIG2 TSHB TSHB NUSAP1 NUSAP1 FOXB1 FOXB1 RFC2 RFC2 RANGAP1 RANGAP1 CBX5 CBX5 G2E3 G2E3 ECT2 ECT2 HMMR HMMR MCM4 MCM4 CRYM CRYM ALDOC ALDOC FEN1 FEN1 CDC6 CDC6 NEK2 NEK2 RRM2 RRM2 LOC108633924 LOC108633924 CENPA CENPA TMPO TMPO MCM5 MCM5 BUB1 BUB1 WDR76 WDR76 KIF20B KIF20B CENPF CENPF TOP2A TOP2A EXO1 EXO1 CDCA8 CDCA8 CDCA3 CDCA3 TACC3 TACC3 BIRC5 BIRC5 LBR LBR CTCF CTCF INSR INSR DSCC1 DSCC1 NASP NASP CCNB2 CCNB2 CDC45 CDC45 GAS2L3 GAS2L3 RAX RAX NCAPD2 NCAPD2 PCNA PCNA USP1 USP1 COL25A1 COL25A1 UBE2C UBE2C CHAF1B CHAF1B GINS2 GINS2 IFNG IFNG POLA1 POLA1 GBX2 GBX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC1A3Amino acid transporter. (542 aa)
ANLNAnillin actin binding protein. (1148 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2323 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
DLGAP5DLG associated protein 5. (843 aa)
CASP8AP2Caspase 8 associated protein 2. (1971 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2431 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
CDCA7Cell division cycle associated 7. (450 aa)
DLX2Distal-less homeobox 2. (328 aa)
CDC25CCell division cycle 25C. (452 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
E2F8E2F transcription factor 8. (866 aa)
CLSPNClaspin. (1339 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
SLC47A1Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (581 aa)
CKAP2Cytoskeleton associated protein 2. (682 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (721 aa)
ATAD2ATPase family AAA domain containing 2. (1385 aa)
NUF2NUF2 component of NDC80 kinetochore complex. (465 aa)
SOX9SRY-box transcription factor 9. (525 aa)
PSRC1Proline and serine rich coiled-coil 1. (326 aa)
NKG7Natural killer cell granule protein 7. (165 aa)
VIMVimentin; Belongs to the intermediate filament family. (471 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (499 aa)
OLIG1Oligodendrocyte transcription factor 1. (259 aa)
GMNNGeminin DNA replication inhibitor. (186 aa)
PIMREGPICALM interacting mitotic regulator. (239 aa)
HELLSHelicase, lymphoid specific. (824 aa)
SLBPStem-loop binding protein. (275 aa)
UBR7UBR-type domain-containing protein. (425 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
CDCA2Cell division cycle associated 2. (1008 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (786 aa)
CKAP5Cytoskeleton associated protein 5. (2040 aa)
KIF11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1055 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1550 aa)
TYMSThymidylate synthetase. (355 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (966 aa)
ANP32EAcidic nuclear phosphoprotein 32 family member E. (231 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
OLIG2Oligodendrocyte transcription factor 2. (329 aa)
TSHBCys_knot domain-containing protein. (158 aa)
NUSAP1Uncharacterized protein. (431 aa)
FOXB1Forkhead box B1. (325 aa)
RFC2Replication factor C subunit 2. (352 aa)
RANGAP1Ran GTPase activating protein 1. (585 aa)
CBX5Chromobox 5. (191 aa)
G2E3G2/M-phase specific E3 ubiquitin protein ligase. (703 aa)
ECT2Epithelial cell transforming 2. (913 aa)
HMMRHyaluronan mediated motility receptor. (715 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
CRYMCrystallin mu. (314 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (493 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa)
NEK2NIMA related kinase 2. (445 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (389 aa)
LOC108633924Histone domain-containing protein. (138 aa)
CENPACentromere protein A. (138 aa)
TMPOThymopoietin. (689 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1090 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (626 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1761 aa)
CENPFCentromere protein F. (3055 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa)
EXO1Exonuclease 1. (835 aa)
CDCA8Cell division cycle associated 8. (280 aa)
CDCA3Cell division cycle associated 3. (265 aa)
TACC3TACC_C domain-containing protein. (743 aa)
BIRC5Uncharacterized protein. (142 aa)
LBRLamin B receptor. (647 aa)
CTCFCCCTC-binding factor. (727 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
DSCC1Uncharacterized protein. (388 aa)
NASPNuclear autoantigenic sperm protein. (770 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
CDC45Cell division cycle 45. (524 aa)
GAS2L3Growth arrest specific 2 like 3. (693 aa)
RAXRetina and anterior neural fold homeobox. (350 aa)
NCAPD2Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1396 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (782 aa)
COL25A1Collagen type XXV alpha 1 chain. (391 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
CHAF1BChromatin assembly factor 1 subunit B. (567 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
POLA1DNA polymerase. (1468 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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