STRINGSTRING
AGPAT1 AGPAT1 ACSL4 ACSL4 IRS2 IRS2 AQP7 AQP7 HSD17B7 HSD17B7 ACSL6 ACSL6 FABP4 FABP4 ACAA1 ACAA1 UCP1 UCP1 PEX7 PEX7 ACADL ACADL ACADS ACADS ELOVL5 ELOVL5 ACTB ACTB AOX1 AOX1 SORBS1 SORBS1 ACOX2 ACOX2 ACACA ACACA AKT2 AKT2 CPT1A CPT1A ADIPOR2 ADIPOR2 PPARG PPARG PRKAB2 PRKAB2 SLC27A2 SLC27A2 PMP2 PMP2 FASN FASN LPIN1 LPIN1 LEP LEP SLC2A4 SLC2A4 LOC102188176 LOC102188176 ACACB ACACB PRKAB1 PRKAB1 ACSL3 ACSL3 ACOX1 ACOX1 UGP2 UGP2 FABP5 FABP5 ACSL1 ACSL1 ACLY ACLY HACD2 HACD2 ANGPTL4 ANGPTL4 CIDEC CIDEC PLIN1 PLIN1 ABCA1 ABCA1 RXRA RXRA SLC27A6 SLC27A6 CD36 CD36 AKT3 AKT3 ARHGEF11 ARHGEF11 MAPK8 MAPK8 LPL LPL PPARA PPARA SLC27A4 SLC27A4 ADIPOQ ADIPOQ ARHGEF12 ARHGEF12 SLC27A1 SLC27A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (323 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
IRS2Insulin receptor substrate 2. (1465 aa)
AQP7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (330 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (358 aa)
ACSL6AMP-binding domain-containing protein. (722 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
PEX7Peroxisomal biogenesis factor 7. (333 aa)
ACADLAcyl-CoA dehydrogenase long chain. (430 aa)
ACADSAcyl-CoA dehydrogenase short chain. (412 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
ACTBUncharacterized protein. (375 aa)
AOX1Aldehyde oxidase 1. (1339 aa)
SORBS1Sorbin and SH3 domain containing 1. (1291 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (682 aa)
ACACAAcetyl-CoA carboxylase alpha. (2329 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
CPT1ACarnitine O-palmitoyltransferase 1; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ADIPOR2Uncharacterized protein. (386 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (271 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
PMP2Peripheral myelin protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
LPIN1Lipin 1. (913 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
SLC2A4MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
LOC102188176FAD-binding PCMH-type domain-containing protein. (1339 aa)
ACACBAcetyl-CoA carboxylase beta. (2448 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (682 aa)
UGP2UTP--glucose-1-phosphate uridylyltransferase. (504 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (719 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (254 aa)
ANGPTL4Angiopoietin like 4. (413 aa)
CIDECCell death inducing DFFA like effector c. (222 aa)
PLIN1Perilipin; Belongs to the perilipin family. (516 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
RXRANR LBD domain-containing protein. (106 aa)
SLC27A6Solute carrier family 27 member 6. (634 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (472 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1508 aa)
MAPK8Mitogen-activated protein kinase. (442 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (487 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
SLC27A4Solute carrier family 27 member 4. (643 aa)
ADIPOQC1q domain-containing protein. (283 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1543 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.