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COX2 COX2 NDUFA1 NDUFA1 SDHD SDHD LOC102168954 LOC102168954 B2M B2M LOC108638252 LOC108638252 SDHC SDHC BBC3 BBC3 SLC25A20 SLC25A20 ATP5F1B ATP5F1B INS INS NRF1 NRF1 ATP5PB ATP5PB TSPO TSPO GOT2 GOT2 ACTB ACTB NDUFB7 NDUFB7 NDUFB8 NDUFB8 SOD1 SOD1 TFAM TFAM ATP5F1A ATP5F1A UQCRC1 UQCRC1 HPRT1 HPRT1 TIMM22 TIMM22 NDUFC1 NDUFC1 UQCRC2 UQCRC2 BNIP3 BNIP3 GSR GSR TOMM34 TOMM34 ATP5MC3 ATP5MC3 LOC102168547 LOC102168547 ALB ALB COX6B2 COX6B2 CASP8 CASP8 GPX6 GPX6 NDUFS6 NDUFS6 ENSCHIP00000023849 ENSCHIP00000023849 SLC25A27 SLC25A27 RPL13A RPL13A FIS1 FIS1 GPX8 GPX8 NDUFV1 NDUFV1 SLC25A24 SLC25A24 VDAC1 VDAC1 GOT1 GOT1 GPX7 GPX7 NDUFB5 NDUFB5 TP53 TP53 SLC25A4 SLC25A4 SLC25A3 SLC25A3 MSTO1 MSTO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa)
NDUFA1NADH:ubiquinone oxidoreductase subunit A1. (70 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
LOC102168954Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
LOC108638252ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
BBC3Uncharacterized protein. (193 aa)
SLC25A20Solute carrier family 25 member 20; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
NRF1Nuclear respiratory factor 1. (503 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (256 aa)
TSPOTranslocator protein. (169 aa)
GOT2Aspartate aminotransferase. (430 aa)
ACTBUncharacterized protein. (375 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (137 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
TFAMTranscription factor A, mitochondrial. (246 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (560 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (480 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
TIMM22Translocase of inner mitochondrial membrane 22. (194 aa)
NDUFC1Uncharacterized protein. (76 aa)
UQCRC2Ubiquinol-cytochrome c reductase core protein 2; Belongs to the peptidase M16 family. (453 aa)
BNIP3BCL2 interacting protein 3. (193 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
TOMM34Translocase of outer mitochondrial membrane 34. (309 aa)
ATP5MC3ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (141 aa)
LOC102168547Beta-2-microglobulin. (124 aa)
ALBSerum albumin. (608 aa)
COX6B2Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
NDUFS6NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (124 aa)
ENSCHIP00000023849Glutathione peroxidase; Belongs to the glutathione peroxidase family. (177 aa)
SLC25A27Solute carrier family 25 member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
RPL13AUncharacterized protein; Belongs to the universal ribosomal protein uL13 family. (203 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
SLC25A24Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (477 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
GOT1Aspartate aminotransferase. (413 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SLC25A3Solute carrier family 25 member 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (362 aa)
MSTO1Misato mitochondrial distribution and morphology regulator 1. (572 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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