STRINGSTRING
NFASC NFASC OTX2 OTX2 CLDN11 CLDN11 INS INS VAMP2 VAMP2 OLIG2 OLIG2 BDNF BDNF PDGFRA PDGFRA NES NES HOXB4 HOXB4 PVALB PVALB LHX2 LHX2 GFAP GFAP HOXB5 HOXB5 NTN1 NTN1 SOX10 SOX10 FGF2 FGF2 HOXB8 HOXB8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFASCNeurofascin. (1180 aa)
OTX2Homeobox domain-containing protein. (289 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (116 aa)
OLIG2Oligodendrocyte transcription factor 2. (329 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
NESNestin; Belongs to the intermediate filament family. (1606 aa)
HOXB4Homeobox B4. (251 aa)
PVALBParvalbumin; Belongs to the parvalbumin family. (111 aa)
LHX2Uncharacterized protein. (422 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
HOXB5Homeobox B5. (269 aa)
NTN1Netrin 1. (496 aa)
SOX10SRY-box transcription factor 10. (469 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
HOXB8Homeobox B8. (243 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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