(23 nodes) (2021) A KLF4PiHLEZH2HMGA2 regulatory axis and its function in promoting oxaliplatin-resistance of colorectal cancer. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102191748	Histone domain-containing protein. (136 aa)
	LOC102185882	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108633554	Histone domain-containing protein. (136 aa)
	LOC102182848	Histone H3; Belongs to the histone H3 family. (136 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	LOC108636012	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108634231	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102180554	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC106503499	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108633916	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102171353	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102169981	Histone domain-containing protein. (136 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	HMGA2	Uncharacterized protein. (104 aa)
	NEB	Nebulin. (6655 aa)
	KLF4	Kruppel like factor 4. (510 aa)
	LOC102189503	Histone H3; Belongs to the histone H3 family. (136 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	MMUT	Methylmalonyl-CoA mutase. (771 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	CTNNB1	Catenin beta 1. (781 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	EZH2	ENSCHIP00000011080	ENSCHIP00000003420	Uncharacterized protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.696
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	H3-4	ENSCHIP00000011080	ENSCHIP00000004038	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	HMGA2	ENSCHIP00000011080	ENSCHIP00000011914	Uncharacterized protein.	Uncharacterized protein.	0.555
ACTB	KLF4	ENSCHIP00000011080	ENSCHIP00000017278	Uncharacterized protein.	Kruppel like factor 4.	0.761
ACTB	LOC102169981	ENSCHIP00000011080	ENSCHIP00000008812	Uncharacterized protein.	Histone domain-containing protein.	0.901
ACTB	LOC102171353	ENSCHIP00000011080	ENSCHIP00000008371	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	LOC102180554	ENSCHIP00000011080	ENSCHIP00000006161	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC102182848	ENSCHIP00000011080	ENSCHIP00000002894	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	LOC102185882	ENSCHIP00000011080	ENSCHIP00000001379	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC102189503	ENSCHIP00000011080	ENSCHIP00000024908	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC102191748	ENSCHIP00000011080	ENSCHIP00000000846	Uncharacterized protein.	Histone domain-containing protein.	0.904
ACTB	LOC106503499	ENSCHIP00000011080	ENSCHIP00000006566	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC108633554	ENSCHIP00000011080	ENSCHIP00000001940	Uncharacterized protein.	Histone domain-containing protein.	0.904
ACTB	LOC108633916	ENSCHIP00000011080	ENSCHIP00000006619	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	LOC108634231	ENSCHIP00000011080	ENSCHIP00000004083	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	LOC108636012	ENSCHIP00000011080	ENSCHIP00000003430	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	MMUT	ENSCHIP00000011080	ENSCHIP00000027222	Uncharacterized protein.	Methylmalonyl-CoA mutase.	0.806