STRINGSTRING
CASP7 CASP7 LOC102176453 LOC102176453 CASP1 CASP1 PXDN PXDN RIPK3 RIPK3 PAX5 PAX5 CASP8 CASP8 MLKL MLKL PAX8 PAX8 MCL1 MCL1 TP53 TP53 IL1B IL1B OGG1 OGG1 XRCC1 XRCC1 EGFR EGFR STAT3 STAT3 FEN1 FEN1 GSDMD GSDMD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
LOC102176453Uncharacterized protein. (291 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (411 aa)
PXDNPeroxidasin. (1525 aa)
RIPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (243 aa)
PAX5Paired box 5. (392 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
MLKLMixed lineage kinase domain like pseudokinase. (471 aa)
PAX8Paired box 8. (457 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
OGG18-oxoguanine DNA glycosylase. (345 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
GSDMDGasdermin D. (483 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.