27 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PLIN2	Perilipin; Belongs to the perilipin family. (378 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
	PXDN	Peroxidasin. (1525 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
	TXNIP	Thioredoxin interacting protein. (391 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (312 aa)
	ALB	Serum albumin. (608 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (181 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
	CA9	Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (445 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	ENSCHIP00000023849	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (177 aa)
	TF	Transferrin; Belongs to the transferrin family. (698 aa)
	AASDH	Aminoadipate-semialdehyde dehydrogenase. (1106 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (719 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	FABP7	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	LYVE1	Lymphatic vessel endothelial hyaluronan receptor 1. (322 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	LOC102168954	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (216 aa)
	ACTB	Uncharacterized protein. (375 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASDH	ACSL1	ENSCHIP00000025675	ENSCHIP00000026081	Aminoadipate-semialdehyde dehydrogenase.	Acyl-CoA synthetase long chain family member 1.	0.766
AASDH	FASN	ENSCHIP00000025675	ENSCHIP00000019407	Aminoadipate-semialdehyde dehydrogenase.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.977
AASDH	PLIN2	ENSCHIP00000025675	ENSCHIP00000011815	Aminoadipate-semialdehyde dehydrogenase.	Perilipin; Belongs to the perilipin family.	0.403
AASDH	PRDX5	ENSCHIP00000025675	ENSCHIP00000007174	Aminoadipate-semialdehyde dehydrogenase.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.432
ACSL1	AASDH	ENSCHIP00000026081	ENSCHIP00000025675	Acyl-CoA synthetase long chain family member 1.	Aminoadipate-semialdehyde dehydrogenase.	0.766
ACSL1	FABP4	ENSCHIP00000026081	ENSCHIP00000004118	Acyl-CoA synthetase long chain family member 1.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.812
ACSL1	FASN	ENSCHIP00000026081	ENSCHIP00000019407	Acyl-CoA synthetase long chain family member 1.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.982
ACSL1	PLIN2	ENSCHIP00000026081	ENSCHIP00000011815	Acyl-CoA synthetase long chain family member 1.	Perilipin; Belongs to the perilipin family.	0.614
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CA9	ENSCHIP00000011080	ENSCHIP00000021659	Uncharacterized protein.	Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family.	0.555
ACTB	ENSCHIP00000023849	ENSCHIP00000011080	ENSCHIP00000023849	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.718
ACTB	FABP4	ENSCHIP00000011080	ENSCHIP00000004118	Uncharacterized protein.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.656
ACTB	FASN	ENSCHIP00000011080	ENSCHIP00000019407	Uncharacterized protein.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.723
ACTB	FTH1	ENSCHIP00000011080	ENSCHIP00000020262	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.551
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GPX6	ENSCHIP00000011080	ENSCHIP00000020908	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.704
ACTB	GPX7	ENSCHIP00000011080	ENSCHIP00000029981	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	GPX8	ENSCHIP00000011080	ENSCHIP00000026386	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	GSR	ENSCHIP00000011080	ENSCHIP00000016690	Uncharacterized protein.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.593
ACTB	HSPB1	ENSCHIP00000011080	ENSCHIP00000015277	Uncharacterized protein.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.718