(46 nodes) (2021) Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
	RPS8	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
	SLC2A4	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (402 aa)
	ANXA1	Annexin. (346 aa)
	CD44	CD44 molecule (Indian blood group). (715 aa)
	EPHB4	EPH receptor B4. (993 aa)
	FABP5	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	SNAP91	Synaptosome associated protein 91. (900 aa)
	LUM	Lumican. (342 aa)
	S100A4	Protein S100; Belongs to the S-100 family. (101 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	LAMB1	Laminin subunit beta 1. (1842 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1607 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	PAX2	Paired box 2. (467 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	ALAS1	5-aminolevulinate synthase. (647 aa)
	RAB21	RAB21, member RAS oncogene family. (222 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	ANXA2	Annexin. (339 aa)
	RAB10	RAB10, member RAS oncogene family. (200 aa)
	TBP	Uncharacterized protein. (327 aa)
	ATP5PO	Uncharacterized protein. (196 aa)
	EEF1A1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
	RAB20	RAB20, member RAS oncogene family. (237 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	COL5A2	Collagen type V alpha 2 chain. (1252 aa)
	ACTB	Uncharacterized protein. (375 aa)
	INSR	Tyrosine-protein kinase receptor. (1365 aa)
	KRT14	Keratin 14; Belongs to the intermediate filament family. (514 aa)
	EPHA3	EPH receptor A3. (984 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	LOC102180556	SERPIN domain-containing protein; Belongs to the serpin family. (390 aa)
	RUNX2	RUNX family transcription factor 2. (585 aa)
	PXDN	Peroxidasin. (1525 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (397 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (745 aa)
	PTPRZ1	Protein tyrosine phosphatase receptor type Z1. (2323 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
	ALB	Serum albumin. (608 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	ANXA1	ENSCHIP00000011080	ENSCHIP00000023293	Uncharacterized protein.	Annexin.	0.799
ACTB	ANXA2	ENSCHIP00000011080	ENSCHIP00000002620	Uncharacterized protein.	Annexin.	0.870
ACTB	CAV1	ENSCHIP00000011080	ENSCHIP00000020742	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.830
ACTB	CD44	ENSCHIP00000011080	ENSCHIP00000024231	Uncharacterized protein.	CD44 molecule (Indian blood group).	0.835
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	EEF1A1	ENSCHIP00000011080	ENSCHIP00000006227	Uncharacterized protein.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.749
ACTB	EIF2S1	ENSCHIP00000011080	ENSCHIP00000007635	Uncharacterized protein.	Eukaryotic translation initiation factor 2 subunit alpha.	0.600
ACTB	EPHB4	ENSCHIP00000011080	ENSCHIP00000024536	Uncharacterized protein.	EPH receptor B4.	0.438
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	INSR	ENSCHIP00000011080	ENSCHIP00000012457	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.568
ACTB	ITGB3	ENSCHIP00000011080	ENSCHIP00000018524	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.969
ACTB	KRAS	ENSCHIP00000011080	ENSCHIP00000032733	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.795
ACTB	KRT14	ENSCHIP00000011080	ENSCHIP00000013319	Uncharacterized protein.	Keratin 14; Belongs to the intermediate filament family.	0.585
ACTB	MYH10	ENSCHIP00000011080	ENSCHIP00000019825	Uncharacterized protein.	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.952
ACTB	MYH9	ENSCHIP00000011080	ENSCHIP00000021370	Uncharacterized protein.	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.964
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	RAB10	ENSCHIP00000011080	ENSCHIP00000003819	Uncharacterized protein.	RAB10, member RAS oncogene family.	0.413
ACTB	RUNX2	ENSCHIP00000011080	ENSCHIP00000015454	Uncharacterized protein.	RUNX family transcription factor 2.	0.834
ACTB	S100A4	ENSCHIP00000011080	ENSCHIP00000030714	Uncharacterized protein.	Protein S100; Belongs to the S-100 family.	0.555