19 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FMR1	Fragile X mental retardation 1. (632 aa)
	CLDN3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	CYFIP2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
	LOC102171808	40S ribosomal protein S27. (84 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	RPL4	Ribos_L4_asso_C domain-containing protein. (434 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	EEF2	Tr-type G domain-containing protein. (858 aa)
	CRLF1	Cytokine receptor like factor 1. (447 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	POLA1	DNA polymerase. (1468 aa)
	POLD1	DNA polymerase. (1115 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (476 aa)
	GMPS	Guanine monophosphate synthase. (693 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	PCNA	ENSCHIP00000003281	ENSCHIP00000015091	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.785
APEX1	POLA1	ENSCHIP00000003281	ENSCHIP00000016749	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA polymerase.	0.428
APEX1	POLD1	ENSCHIP00000003281	ENSCHIP00000019836	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA polymerase.	0.706
APEX1	TP53	ENSCHIP00000003281	ENSCHIP00000030141	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.548
CASP3	CASP9	ENSCHIP00000011490	ENSCHIP00000008590	Caspase 3; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.991
CASP3	CCND1	ENSCHIP00000011490	ENSCHIP00000006815	Caspase 3; Belongs to the peptidase C14A family.	Cyclin D1; Belongs to the cyclin family.	0.891
CASP3	TP53	ENSCHIP00000011490	ENSCHIP00000030141	Caspase 3; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.941
CASP9	CASP3	ENSCHIP00000008590	ENSCHIP00000011490	Caspase 9; Belongs to the peptidase C14A family.	Caspase 3; Belongs to the peptidase C14A family.	0.991
CASP9	CCND1	ENSCHIP00000008590	ENSCHIP00000006815	Caspase 9; Belongs to the peptidase C14A family.	Cyclin D1; Belongs to the cyclin family.	0.872
CASP9	TP53	ENSCHIP00000008590	ENSCHIP00000030141	Caspase 9; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.943
CCND1	CASP3	ENSCHIP00000006815	ENSCHIP00000011490	Cyclin D1; Belongs to the cyclin family.	Caspase 3; Belongs to the peptidase C14A family.	0.891
CCND1	CASP9	ENSCHIP00000006815	ENSCHIP00000008590	Cyclin D1; Belongs to the cyclin family.	Caspase 9; Belongs to the peptidase C14A family.	0.872
CCND1	PCNA	ENSCHIP00000006815	ENSCHIP00000015091	Cyclin D1; Belongs to the cyclin family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.963
CCND1	TP53	ENSCHIP00000006815	ENSCHIP00000030141	Cyclin D1; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.901
CYFIP2	FMR1	ENSCHIP00000004003	ENSCHIP00000000274	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	Fragile X mental retardation 1.	0.987
EEF2	GMPS	ENSCHIP00000011994	ENSCHIP00000026603	Tr-type G domain-containing protein.	Guanine monophosphate synthase.	0.408
EEF2	LOC102171808	ENSCHIP00000011994	ENSCHIP00000006649	Tr-type G domain-containing protein.	40S ribosomal protein S27.	0.586
EEF2	RPL4	ENSCHIP00000011994	ENSCHIP00000009673	Tr-type G domain-containing protein.	Ribos_L4_asso_C domain-containing protein.	0.881
EEF2	RPS27A	ENSCHIP00000011994	ENSCHIP00000011667	Tr-type G domain-containing protein.	Ubiquitin-like domain-containing protein.	0.774
FMR1	CYFIP2	ENSCHIP00000000274	ENSCHIP00000004003	Fragile X mental retardation 1.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.987