15 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NES	Nestin; Belongs to the intermediate filament family. (1606 aa)
	PAX6	Paired box 6. (486 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	BRCA2	BRCA2 DNA repair associated. (3405 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
	ALB	Serum albumin. (608 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	WRN	WRN RecQ like helicase. (1405 aa)
	ACTB	Uncharacterized protein. (375 aa)
	NANOG	Homeobox domain-containing protein. (300 aa)
	CD34	Uncharacterized protein. (384 aa)
	SMARCAL1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
	ZRANB3	Zinc finger RANBP2-type containing 3. (1070 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	HLTF	Helicase like transcription factor. (1011 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	BRCA2	ENSCHIP00000011080	ENSCHIP00000024039	Uncharacterized protein.	BRCA2 DNA repair associated.	0.617
ACTB	CD34	ENSCHIP00000011080	ENSCHIP00000002645	Uncharacterized protein.	Uncharacterized protein.	0.812
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	MDM2	ENSCHIP00000011080	ENSCHIP00000021696	Uncharacterized protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.771
ACTB	NANOG	ENSCHIP00000011080	ENSCHIP00000009313	Uncharacterized protein.	Homeobox domain-containing protein.	0.781
ACTB	NES	ENSCHIP00000011080	ENSCHIP00000032395	Uncharacterized protein.	Nestin; Belongs to the intermediate filament family.	0.800
ACTB	PAX6	ENSCHIP00000011080	ENSCHIP00000027464	Uncharacterized protein.	Paired box 6.	0.674
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	BRCA2	ENSCHIP00000020234	ENSCHIP00000024039	Serum albumin.	BRCA2 DNA repair associated.	0.503
ALB	CD34	ENSCHIP00000020234	ENSCHIP00000002645	Serum albumin.	Uncharacterized protein.	0.856
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948
ALB	MDM2	ENSCHIP00000020234	ENSCHIP00000021696	Serum albumin.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.619
ALB	NANOG	ENSCHIP00000020234	ENSCHIP00000009313	Serum albumin.	Homeobox domain-containing protein.	0.876
ALB	NES	ENSCHIP00000020234	ENSCHIP00000032395	Serum albumin.	Nestin; Belongs to the intermediate filament family.	0.817
ALB	PAX6	ENSCHIP00000020234	ENSCHIP00000027464	Serum albumin.	Paired box 6.	0.691
ALB	TP53	ENSCHIP00000020234	ENSCHIP00000030141	Serum albumin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.844
BRCA2	ACTB	ENSCHIP00000024039	ENSCHIP00000011080	BRCA2 DNA repair associated.	Uncharacterized protein.	0.617
BRCA2	ALB	ENSCHIP00000024039	ENSCHIP00000020234	BRCA2 DNA repair associated.	Serum albumin.	0.503