(24 nodes) (2021) Variants in a cis-regulatory element of TBX1 in conotruncal heart defect patients impair GATA6-mediated transactivation. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SOX9	SRY-box transcription factor 9. (525 aa)
	RIPPLY3	Ripply transcriptional repressor 3. (178 aa)
	GATA1	GATA binding protein 1. (413 aa)
	PITX2	Homeobox protein. (325 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TBX15	T-box transcription factor 15. (602 aa)
	GATA5	GATA binding protein 5. (403 aa)
	ENSCHIP00000015051	Uncharacterized protein. (385 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	MEF2C	MADS-box domain-containing protein. (441 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (765 aa)
	PAX9	Paired box 9. (342 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	SNAI3	Snail family transcriptional repressor 3. (291 aa)
	GATA6	GATA binding protein 6. (592 aa)
	NFATC1	Nuclear factor of activated T cells 1. (1002 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	TBX5	T-box transcription factor 5. (594 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENSCHIP00000015051	ENSCHIP00000023678	ENSCHIP00000015051	Bone morphogenetic protein 4.	Uncharacterized protein.	0.475
BMP4	FGF10	ENSCHIP00000023678	ENSCHIP00000010028	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.887
BMP4	FGF8	ENSCHIP00000023678	ENSCHIP00000016903	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.763
BMP4	GAPDH	ENSCHIP00000023678	ENSCHIP00000025974	Bone morphogenetic protein 4.	Glyceraldehyde-3-phosphate dehydrogenase.	0.761
BMP4	GATA1	ENSCHIP00000023678	ENSCHIP00000004852	Bone morphogenetic protein 4.	GATA binding protein 1.	0.462
BMP4	GATA5	ENSCHIP00000023678	ENSCHIP00000012846	Bone morphogenetic protein 4.	GATA binding protein 5.	0.592
BMP4	GATA6	ENSCHIP00000023678	ENSCHIP00000020060	Bone morphogenetic protein 4.	GATA binding protein 6.	0.773
BMP4	HAND2	ENSCHIP00000023678	ENSCHIP00000009629	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.682
BMP4	ISL1	ENSCHIP00000023678	ENSCHIP00000025978	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.733
BMP4	MEF2C	ENSCHIP00000023678	ENSCHIP00000015775	Bone morphogenetic protein 4.	MADS-box domain-containing protein.	0.577
BMP4	NKX2-5	ENSCHIP00000023678	ENSCHIP00000017688	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.693
BMP4	PAX9	ENSCHIP00000023678	ENSCHIP00000017561	Bone morphogenetic protein 4.	Paired box 9.	0.582
BMP4	PITX2	ENSCHIP00000023678	ENSCHIP00000006749	Bone morphogenetic protein 4.	Homeobox protein.	0.566
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SOX9	ENSCHIP00000023678	ENSCHIP00000024523	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.769
BMP4	TBX5	ENSCHIP00000023678	ENSCHIP00000028388	Bone morphogenetic protein 4.	T-box transcription factor 5.	0.692
BMP4	WNT2	ENSCHIP00000023678	ENSCHIP00000007601	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.465
BMP4	WNT5A	ENSCHIP00000023678	ENSCHIP00000015533	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.731
ENSCHIP00000015051	BMP4	ENSCHIP00000015051	ENSCHIP00000023678	Uncharacterized protein.	Bone morphogenetic protein 4.	0.475
ENSCHIP00000015051	GATA6	ENSCHIP00000015051	ENSCHIP00000020060	Uncharacterized protein.	GATA binding protein 6.	0.890