28 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	E2F4	E2F transcription factor 4. (405 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (430 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (851 aa)
	POLD1	DNA polymerase. (1115 aa)
	LIN37	Lin-37 DREAM MuvB core complex component. (240 aa)
	DNA2	DNA replication helicase/nuclease 2. (1062 aa)
	MMS22L	MMS22 like, DNA repair protein. (1244 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (808 aa)
	BRCA2	BRCA2 DNA repair associated. (3405 aa)
	BARD1	BRCA1 associated RING domain 1. (775 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	LIN54	Lin-54 DREAM MuvB core complex component. (748 aa)
	FANCD2	FA complementation group D2. (1423 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	PALB2	Partner and localizer of BRCA2. (1194 aa)
	FSBP	Uncharacterized protein. (909 aa)
	LIG4	DNA ligase. (911 aa)
	RAD51B	RAD51 paralog B. (270 aa)
	MCM8	MCM domain-containing protein; Belongs to the MCM family. (832 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (421 aa)
	EXO1	Exonuclease 1. (835 aa)
	E2F5	E2F transcription factor 5. (314 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (734 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSCHIP00000024535	ENSCHIP00000033014	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRCA2	ENSCHIP00000024535	ENSCHIP00000024039	BRCA1 associated RING domain 1.	BRCA2 DNA repair associated.	0.987
BARD1	CCNA1	ENSCHIP00000024535	ENSCHIP00000011874	BRCA1 associated RING domain 1.	Cyclin A1; Belongs to the cyclin family.	0.490
BARD1	CCNA2	ENSCHIP00000024535	ENSCHIP00000018235	BRCA1 associated RING domain 1.	Cyclin A2; Belongs to the cyclin family.	0.630
BARD1	CDK6	ENSCHIP00000024535	ENSCHIP00000008415	BRCA1 associated RING domain 1.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.586
BARD1	DNA2	ENSCHIP00000024535	ENSCHIP00000020258	BRCA1 associated RING domain 1.	DNA replication helicase/nuclease 2.	0.742
BARD1	EXO1	ENSCHIP00000024535	ENSCHIP00000010493	BRCA1 associated RING domain 1.	Exonuclease 1.	0.845
BARD1	FANCD2	ENSCHIP00000024535	ENSCHIP00000032582	BRCA1 associated RING domain 1.	FA complementation group D2.	0.802
BARD1	FSBP	ENSCHIP00000024535	ENSCHIP00000004011	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.479
BARD1	LIG4	ENSCHIP00000024535	ENSCHIP00000000867	BRCA1 associated RING domain 1.	DNA ligase.	0.616
BARD1	MCM7	ENSCHIP00000024535	ENSCHIP00000033687	BRCA1 associated RING domain 1.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.459
BARD1	MMS22L	ENSCHIP00000024535	ENSCHIP00000020862	BRCA1 associated RING domain 1.	MMS22 like, DNA repair protein.	0.588
BARD1	PALB2	ENSCHIP00000024535	ENSCHIP00000006272	BRCA1 associated RING domain 1.	Partner and localizer of BRCA2.	0.982
BARD1	PCNA	ENSCHIP00000024535	ENSCHIP00000015091	BRCA1 associated RING domain 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.544
BARD1	POLD1	ENSCHIP00000024535	ENSCHIP00000019836	BRCA1 associated RING domain 1.	DNA polymerase.	0.618
BARD1	RAD51B	ENSCHIP00000024535	ENSCHIP00000012969	BRCA1 associated RING domain 1.	RAD51 paralog B.	0.799
BCL2	BRCA1	ENSCHIP00000015831	ENSCHIP00000033014	BH4_2 domain-containing protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.694
BCL2	CCNA1	ENSCHIP00000015831	ENSCHIP00000011874	BH4_2 domain-containing protein.	Cyclin A1; Belongs to the cyclin family.	0.743
BCL2	CCNA2	ENSCHIP00000015831	ENSCHIP00000018235	BH4_2 domain-containing protein.	Cyclin A2; Belongs to the cyclin family.	0.751
BCL2	CDK6	ENSCHIP00000015831	ENSCHIP00000008415	BH4_2 domain-containing protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.793