28 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	SLC1A6	Amino acid transporter. (564 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (389 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	LIN28B	Lin-28 homolog B. (255 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	ACTB	Uncharacterized protein. (375 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (579 aa)
	SLC1A3	Amino acid transporter. (542 aa)
	SLC1A1	Amino acid transporter. (534 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	RRM1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
	SLC1A7	Amino acid transporter. (574 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
	SLC1A5	Amino acid transporter. (530 aa)
	PDK2	Protein-serine/threonine kinase. (407 aa)
	HNRNPA2B1	Heterogeneous nuclear ribonucleoprotein A2/B1. (353 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	SLC1A4	Solute carrier family 1 member 4. (527 aa)
	SLC1A2	Amino acid transporter. (578 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CCNE2	ENSCHIP00000011080	ENSCHIP00000026359	Uncharacterized protein.	Cyclin E2; Belongs to the cyclin family.	0.664
ACTB	CDK1	ENSCHIP00000011080	ENSCHIP00000000505	Uncharacterized protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.790
ACTB	CDK6	ENSCHIP00000011080	ENSCHIP00000008415	Uncharacterized protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.793
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	LIN28B	ENSCHIP00000011080	ENSCHIP00000007713	Uncharacterized protein.	Lin-28 homolog B.	0.432
ACTB	MDM2	ENSCHIP00000011080	ENSCHIP00000021696	Uncharacterized protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.771
ACTB	MYH9	ENSCHIP00000011080	ENSCHIP00000021370	Uncharacterized protein.	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.964
ACTB	PDK2	ENSCHIP00000011080	ENSCHIP00000025394	Uncharacterized protein.	Protein-serine/threonine kinase.	0.419
ACTB	RRM2	ENSCHIP00000011080	ENSCHIP00000005712	Uncharacterized protein.	Ribonucleotide reductase regulatory subunit M2.	0.424
ACTB	SLC1A1	ENSCHIP00000011080	ENSCHIP00000019349	Uncharacterized protein.	Amino acid transporter.	0.497
ACTB	SLC1A2	ENSCHIP00000011080	ENSCHIP00000033328	Uncharacterized protein.	Amino acid transporter.	0.474
ACTB	SLC1A3	ENSCHIP00000011080	ENSCHIP00000017001	Uncharacterized protein.	Amino acid transporter.	0.472
ACTB	SLC1A5	ENSCHIP00000011080	ENSCHIP00000023350	Uncharacterized protein.	Amino acid transporter.	0.515
ACTB	SLC1A6	ENSCHIP00000011080	ENSCHIP00000005613	Uncharacterized protein.	Amino acid transporter.	0.495
ACTB	SLC1A7	ENSCHIP00000011080	ENSCHIP00000021080	Uncharacterized protein.	Amino acid transporter.	0.495
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
CCND1	ACTB	ENSCHIP00000006815	ENSCHIP00000011080	Cyclin D1; Belongs to the cyclin family.	Uncharacterized protein.	0.890
CCND1	CCNE2	ENSCHIP00000006815	ENSCHIP00000026359	Cyclin D1; Belongs to the cyclin family.	Cyclin E2; Belongs to the cyclin family.	0.738
CCND1	CDK1	ENSCHIP00000006815	ENSCHIP00000000505	Cyclin D1; Belongs to the cyclin family.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.978