(15 nodes) (2021) Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	APLN	Apelin. (72 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	CCL2	C-C motif chemokine. (98 aa)
	CD63	Tetraspanin. (237 aa)
	ALB	Serum albumin. (608 aa)
	GAP43	Growth associated protein 43. (238 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	CD9	Tetraspanin. (226 aa)
	ZDHHC1	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (531 aa)
	CD81	Tetraspanin. (236 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	ACTB	Uncharacterized protein. (375 aa)
	TSG101	Uncharacterized protein. (391 aa)
	CXCL10	C-X-C motif chemokine. (102 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	APLN	ENSCHIP00000011080	ENSCHIP00000015839	Uncharacterized protein.	Apelin.	0.430
ACTB	CCL2	ENSCHIP00000011080	ENSCHIP00000027804	Uncharacterized protein.	C-C motif chemokine.	0.764
ACTB	CD63	ENSCHIP00000011080	ENSCHIP00000023741	Uncharacterized protein.	Tetraspanin.	0.795
ACTB	CD81	ENSCHIP00000011080	ENSCHIP00000005620	Uncharacterized protein.	Tetraspanin.	0.723
ACTB	CD9	ENSCHIP00000011080	ENSCHIP00000004782	Uncharacterized protein.	Tetraspanin.	0.782
ACTB	CXCL10	ENSCHIP00000011080	ENSCHIP00000014303	Uncharacterized protein.	C-X-C motif chemokine.	0.738
ACTB	GAP43	ENSCHIP00000011080	ENSCHIP00000019508	Uncharacterized protein.	Growth associated protein 43.	0.620
ACTB	IFNG	ENSCHIP00000011080	ENSCHIP00000016152	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.875
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	IL6	ENSCHIP00000011080	ENSCHIP00000009414	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.919
ACTB	TSG101	ENSCHIP00000011080	ENSCHIP00000011190	Uncharacterized protein.	Uncharacterized protein.	0.736
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	CCL2	ENSCHIP00000020234	ENSCHIP00000027804	Serum albumin.	C-C motif chemokine.	0.748
ALB	CD63	ENSCHIP00000020234	ENSCHIP00000023741	Serum albumin.	Tetraspanin.	0.868
ALB	CD81	ENSCHIP00000020234	ENSCHIP00000005620	Serum albumin.	Tetraspanin.	0.720
ALB	CD9	ENSCHIP00000020234	ENSCHIP00000004782	Serum albumin.	Tetraspanin.	0.750
ALB	CXCL10	ENSCHIP00000020234	ENSCHIP00000014303	Serum albumin.	C-X-C motif chemokine.	0.700
ALB	GAP43	ENSCHIP00000020234	ENSCHIP00000019508	Serum albumin.	Growth associated protein 43.	0.633
ALB	IFNG	ENSCHIP00000020234	ENSCHIP00000016152	Serum albumin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.893