STRINGSTRING
SHH SHH GLI1 GLI1 MFNG MFNG DLL3 DLL3 NRARP NRARP SIX3 SIX3 SLIT1 SLIT1 PRCP PRCP LHX6 LHX6 TBX3 TBX3 FGF10 FGF10 ASCL1 ASCL1 PTCH1 PTCH1 STMN2 STMN2 TBX2 TBX2 PXDN PXDN WNT5A WNT5A GLI2 GLI2 LRP2 LRP2 DLL1 DLL1 BMP4 BMP4 NOTCH1 NOTCH1 POU5F1 POU5F1 HEY1 HEY1 RBPJ RBPJ GAPDH GAPDH ISL1 ISL1 FOXG1 FOXG1 PAX6 PAX6 NKX2-1 NKX2-1 DLX2 DLX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
GLI1GLI family zinc finger 1. (1105 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (320 aa)
DLL3Delta like canonical Notch ligand 3. (595 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
SIX3SIX homeobox 3. (325 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
PRCPProlylcarboxypeptidase. (511 aa)
LHX6LIM homeobox 6. (385 aa)
TBX3T-box transcription factor 3. (749 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
PTCH1Patched 1. (1453 aa)
STMN2Stathmin; Belongs to the stathmin family. (181 aa)
TBX2T-box transcription factor 2. (771 aa)
PXDNPeroxidasin. (1525 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
GLI2GLI family zinc finger 2. (1565 aa)
LRP2LDL receptor related protein 2. (4649 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NOTCH1Notch receptor 1. (2508 aa)
POU5F1POU domain protein. (360 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (513 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
ISL1ISL LIM homeobox 1. (349 aa)
FOXG1Forkhead box G1. (538 aa)
PAX6Paired box 6. (486 aa)
NKX2-1NK2 homeobox 1. (370 aa)
DLX2Distal-less homeobox 2. (328 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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