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HLTF HLTF MUS81 MUS81 EXD2 EXD2 BRCA2 BRCA2 SMARCAL1 SMARCAL1 ZRANB3 ZRANB3 FANCD2 FANCD2 BRCA1 BRCA1 TOP1 TOP1 WRN WRN PCNA PCNA PARP1 PARP1 FANCA FANCA RAD52 RAD52 EXO1 EXO1 ACTB ACTB DNA2 DNA2 LMNB1 LMNB1 WRNIP1 WRNIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLTFHelicase like transcription factor. (1011 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
EXD2Exonuclease 3'-5' domain containing 2. (642 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1070 aa)
FANCD2FA complementation group D2. (1423 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
WRNWRN RecQ like helicase. (1405 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
FANCAFA complementation group A. (1416 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
EXO1Exonuclease 1. (835 aa)
ACTBUncharacterized protein. (375 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
WRNIP1WRN helicase interacting protein 1. (640 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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