STRINGSTRING
CD4 CD4 TGFB3 TGFB3 CD34 CD34 BHLHA15 BHLHA15 COL10A1 COL10A1 HGF HGF TGFB1 TGFB1 IL6 IL6 FAH FAH GOT2 GOT2 GSK3B GSK3B FGF7 FGF7 ASL ASL PPARG PPARG RUNX2 RUNX2 IFNG IFNG MMP9 MMP9 ARG2 ARG2 ASS1 ASS1 ACTA2 ACTA2 CDH1 CDH1 FGF2 FGF2 TAT TAT FASN FASN ALB ALB OSM OSM JAG1 JAG1 COL1A1 COL1A1 SOX9 SOX9 NOTCH2 NOTCH2 TGFB2 TGFB2 CD19 CD19 KRT18 KRT18 GOT1 GOT1 TIMP2 TIMP2 CPS1 CPS1 LPL LPL BGLAP BGLAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD4CD4 molecule. (455 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
CD34Uncharacterized protein. (384 aa)
BHLHA15Basic helix-loop-helix family member a15. (186 aa)
COL10A1Collagen type X alpha 1 chain. (674 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
FAHFumarylacetoacetase. (419 aa)
GOT2Aspartate aminotransferase. (430 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ASLUncharacterized protein. (473 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
MMP9Uncharacterized protein. (709 aa)
ARG2Arginase. (354 aa)
ASS1Argininosuccinate synthase 1. (426 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (903 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (447 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
ALBSerum albumin. (608 aa)
OSMOncostatin M. (239 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
SOX9SRY-box transcription factor 9. (525 aa)
NOTCH2Notch receptor 2. (2471 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CD19CD19 molecule. (561 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
GOT1Aspartate aminotransferase. (413 aa)
TIMP2TIMP metallopeptidase inhibitor 2. (220 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (487 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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