STRINGSTRING
LRP5 LRP5 LEP LEP SOST SOST RSPO2 RSPO2 CRTAP CRTAP AXIN2 AXIN2 COL1A1 COL1A1 IBSP IBSP PRP1 PRP1 WNT11 WNT11 FKBP10 FKBP10 GAPDH GAPDH MAF MAF IFITM5 IFITM5 LOC102180550 LOC102180550 BMP1 BMP1 MMUT MMUT LOC102171116 LOC102171116 LGR6 LGR6 CTNNB1 CTNNB1 COL1A2 COL1A2 BGLAP BGLAP SERPINF1 SERPINF1 LGR4 LGR4 JUN JUN PTH PTH CREB3L1 CREB3L1 PRP6 PRP6 ZNRF3 ZNRF3 ALPL ALPL LOC102170569 LOC102170569 LOC102184390 LOC102184390 LOC102190477 LOC102190477 MAPK9 MAPK9 DKK1 DKK1 LRP6 LRP6 CRP CRP RSPO4 RSPO4 LOC102178616 LOC102178616 RUNX2 RUNX2 WNT3A WNT3A ROCK1 ROCK1 WNT16 WNT16 LOC108638107 LOC108638107 LGR5 LGR5 PLS3 PLS3 WNT1 WNT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
SOSTSclerostin. (212 aa)
RSPO2R-spondin 2. (243 aa)
CRTAPCartilage associated protein. (404 aa)
AXIN2Axin 2. (844 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
IBSPIntegrin binding sialoprotein. (306 aa)
PRP1Prolactin-related protein-1. (238 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FKBP10Peptidylprolyl isomerase. (574 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (404 aa)
IFITM5Interferon induced transmembrane protein 5. (134 aa)
LOC102180550Uncharacterized protein. (237 aa)
BMP1Metalloendopeptidase. (988 aa)
MMUTMethylmalonyl-CoA mutase. (771 aa)
LOC102171116Uncharacterized protein. (226 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (902 aa)
CTNNB1Catenin beta 1. (781 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (416 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (581 aa)
PRP6Prolactin-related protein-6. (239 aa)
ZNRF3Zinc and ring finger 3. (941 aa)
ALPLAlkaline phosphatase. (524 aa)
LOC102170569Uncharacterized protein. (211 aa)
LOC102184390Uncharacterized protein. (287 aa)
LOC102190477Uncharacterized protein. (238 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CRPPentaxin. (227 aa)
RSPO4R-spondin 4. (232 aa)
LOC102178616Uncharacterized protein. (265 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
LOC108638107Uncharacterized protein. (238 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
PLS3Plastin 3. (639 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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