STRINGSTRING
JAK2 JAK2 MBP MBP MAP2 MAP2 TGFB3 TGFB3 PDGFRA PDGFRA SRC SRC BDNF BDNF NEUROG2 NEUROG2 CNP CNP HGF HGF SOX2 SOX2 NFIA NFIA TGFB1 TGFB1 NTF3 NTF3 HOXC6 HOXC6 MNX1 MNX1 LIF LIF IRX3 IRX3 HOXB8 HOXB8 HOXB1 HOXB1 IGF1 IGF1 OLIG1 OLIG1 SOX10 SOX10 STAT3 STAT3 VIM VIM ISL1 ISL1 TGFB2 TGFB2 HOXB9 HOXB9 HOXB5 HOXB5 PAX6 PAX6 SHH SHH CCN2 CCN2 NKX2-2 NKX2-2 HOXB4 HOXB4 NES NES ZIC1 ZIC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK2Tyrosine-protein kinase. (1132 aa)
MBPUncharacterized protein. (191 aa)
MAP2Microtubule-associated protein. (1868 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
SRCTyrosine-protein kinase. (538 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
NEUROG2Neurogenin 2. (270 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (421 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
SOX2HMG box domain-containing protein. (320 aa)
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (509 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (266 aa)
HOXC6Homeobox C6. (235 aa)
MNX1Motor neuron and pancreas homeobox 1. (411 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
IRX3Iroquois homeobox 3. (503 aa)
HOXB8Homeobox B8. (243 aa)
HOXB1Homeobox B1. (302 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
OLIG1Oligodendrocyte transcription factor 1. (259 aa)
SOX10SRY-box transcription factor 10. (469 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
VIMVimentin; Belongs to the intermediate filament family. (471 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
HOXB5Homeobox B5. (269 aa)
PAX6Paired box 6. (486 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
CCN2Cellular communication network factor 2. (349 aa)
NKX2-2NK2 homeobox 2. (273 aa)
HOXB4Homeobox B4. (251 aa)
NESNestin; Belongs to the intermediate filament family. (1606 aa)
ZIC1Zic family member 1. (447 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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