STRINGSTRING
ILF3 ILF3 TP53 TP53 PAPOLA PAPOLA SRSF11 SRSF11 TUBB TUBB FTSJ3 FTSJ3 MATR3 MATR3 DAGLB DAGLB BAZ2A BAZ2A KAT7 KAT7 SMARCA2 SMARCA2 ZC3H15 ZC3H15 CNOT9 CNOT9 LIMA1 LIMA1 APP APP SLFN11 SLFN11 NLGN1 NLGN1 RCC1 RCC1 TFRC TFRC ITPKC ITPKC SUPV3L1 SUPV3L1 FMR1 FMR1 DDX21 DDX21 CCAR1 CCAR1 BCLAF1 BCLAF1 ANP32E ANP32E RHOQ RHOQ EIF2S3 EIF2S3 FUS FUS HNRNPU HNRNPU EIF3E EIF3E H1-4 H1-4 S100A13 S100A13 BASP1 BASP1 RAD50 RAD50 SMARCC1 SMARCC1 NRXN3 NRXN3 BRD3 BRD3 UPF3A UPF3A SNRNP40 SNRNP40 TPM4 TPM4 ENSCHIP00000005826 ENSCHIP00000005826 HSP90B1 HSP90B1 EIF4G1 EIF4G1 CBX3 CBX3 IQGAP1 IQGAP1 SMC6 SMC6 LOC102182127 LOC102182127 HNRNPDL HNRNPDL LOC102171676 LOC102171676 SRRT SRRT ARID1A ARID1A CPEB4 CPEB4 KCNQ2 KCNQ2 SMC3 SMC3 DCAF12 DCAF12 CHD7 CHD7 OXCT1 OXCT1 RAB11A RAB11A SMARCE1 SMARCE1 KIF20B KIF20B RBM33 RBM33 UBE2T UBE2T SUDS3 SUDS3 LUC7L3 LUC7L3 PHF6 PHF6 ACTB ACTB TARS1 TARS1 LMNB1 LMNB1 MAP1B MAP1B SMARCA5 SMARCA5 HMGA2 HMGA2 YBX1 YBX1 LSM8 LSM8 PRPF4B PRPF4B ELAVL1 ELAVL1 NASP NASP C9orf72 C9orf72 ZMAT2 ZMAT2 HNRNPK HNRNPK PAPOLG PAPOLG STX6 STX6 SMARCA4 SMARCA4 HNRNPA3 HNRNPA3 CARHSP1 CARHSP1 NUCKS1 NUCKS1 BRD9 BRD9 SRSF6 SRSF6 USP1 USP1 HOOK3 HOOK3 KLHL11 KLHL11 NRXN1 NRXN1 YLPM1 YLPM1 RBM20 RBM20 SMC5 SMC5 NSMF NSMF THOC2 THOC2 TUBA1B TUBA1B PRRC2C PRRC2C FASN FASN RSL1D1 RSL1D1 SMC4 SMC4 BAZ1B BAZ1B SMARCC2 SMARCC2 SRSF7 SRSF7 MBNL1 MBNL1 AP2B1 AP2B1 HELLS HELLS MCM2 MCM2 CARMIL1 CARMIL1 PCBP2 PCBP2 EIF1 EIF1 NOM1 NOM1 KDM5B KDM5B NRXN2 NRXN2 HUWE1 HUWE1 CTSL CTSL TRUB1 TRUB1 ZEB2 ZEB2 SAP30BP SAP30BP NSRP1 NSRP1 TMOD3 TMOD3 TUBB2B TUBB2B DNAJC2 DNAJC2 MACROH2A1 MACROH2A1 THOC3 THOC3 GET4 GET4 PFDN2 PFDN2 H1-2 H1-2 LOC102189503 LOC102189503 CDC5L CDC5L SRSF4 SRSF4 HSP90AA1 HSP90AA1 GAPDH GAPDH HNRNPC HNRNPC USP36 USP36 ZC3H14 ZC3H14 TUBA1A TUBA1A SFPQ SFPQ PPP2R1A PPP2R1A PABPC1 PABPC1 SNRPE SNRPE HDAC2 HDAC2 TACC1 TACC1 PWP1 PWP1 MEF2A MEF2A RBM39 RBM39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ILF3Interleukin enhancer binding factor 3. (899 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
PAPOLAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (739 aa)
SRSF11Serine and arginine rich splicing factor 11. (429 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
FTSJ3pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (832 aa)
MATR3Uncharacterized protein. (849 aa)
DAGLBDiacylglycerol lipase beta. (669 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1888 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1572 aa)
ZC3H15Uncharacterized protein. (417 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
LIMA1LIM domain and actin binding 1. (760 aa)
APPAmyloid beta precursor protein. (770 aa)
SLFN11Schlafen family member 11. (909 aa)
NLGN1Neuroligin 1. (509 aa)
RCC1Regulator of chromosome condensation 1. (444 aa)
TFRCTransferrin receptor. (790 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (676 aa)
SUPV3L1Suv3 like RNA helicase. (787 aa)
FMR1Fragile X mental retardation 1. (632 aa)
DDX21Uncharacterized protein. (754 aa)
CCAR1Cell division cycle and apoptosis regulator 1. (1149 aa)
BCLAF1BCL2 associated transcription factor 1. (943 aa)
ANP32EAcidic nuclear phosphoprotein 32 family member E. (231 aa)
RHOQRas homolog family member Q. (205 aa)
EIF2S3Tr-type G domain-containing protein. (472 aa)
FUSFUS RNA binding protein. (522 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
BASP1Brain abundant membrane attached signal protein 1. (228 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1093 aa)
NRXN3Uncharacterized protein. (312 aa)
BRD3Bromodomain containing 3. (722 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (503 aa)
SNRNP40Small nuclear ribonucleoprotein U5 subunit 40. (358 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
ENSCHIP00000005826Uncharacterized protein. (327 aa)
HSP90B1Heat shock protein 90 beta family member 1. (836 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1607 aa)
CBX3Uncharacterized protein. (183 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
SMC6Structural maintenance of chromosomes 6. (1116 aa)
LOC102182127Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (439 aa)
HNRNPDLUncharacterized protein. (420 aa)
LOC102171676Histone H2A; Belongs to the histone H2A family. (129 aa)
SRRTSerrate, RNA effector molecule. (876 aa)
ARID1AAT-rich interaction domain 1A. (2285 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (909 aa)
SMC3Structural maintenance of chromosomes protein. (1231 aa)
DCAF12DDB1 and CUL4 associated factor 12. (453 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2993 aa)
OXCT1Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (530 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1761 aa)
RBM33RNA binding motif protein 33. (1129 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
SUDS3SDS3 homolog, SIN3A corepressor complex component. (324 aa)
LUC7L3LUC7 like 3 pre-mRNA splicing factor. (491 aa)
PHF6PHD finger protein 6. (366 aa)
ACTBUncharacterized protein. (375 aa)
TARS1Threonyl-tRNA synthetase. (723 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
SMARCA5Uncharacterized protein. (1052 aa)
HMGA2Uncharacterized protein. (104 aa)
YBX1CSD_1 domain-containing protein. (324 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (94 aa)
PRPF4BPre-mRNA processing factor 4B. (1072 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
NASPNuclear autoantigenic sperm protein. (770 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
ZMAT2Zinc finger matrin-type 2. (199 aa)
HNRNPKUncharacterized protein. (454 aa)
PAPOLGPoly(A) polymerase gamma. (740 aa)
STX6Syntaxin 6; Belongs to the syntaxin family. (238 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1606 aa)
HNRNPA3Uncharacterized protein. (361 aa)
CARHSP1Calcium regulated heat stable protein 1. (147 aa)
NUCKS1Uncharacterized protein. (248 aa)
BRD9Bromodomain containing 9. (577 aa)
SRSF6Uncharacterized protein. (345 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (782 aa)
HOOK3Hook microtubule tethering protein 3. (719 aa)
KLHL11Kelch like family member 11. (708 aa)
NRXN1Neurexin 1. (853 aa)
YLPM1YLP motif containing 1. (2145 aa)
RBM20RNA binding motif protein 20. (1230 aa)
SMC5AAA_23 domain-containing protein. (1104 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (530 aa)
THOC2Uncharacterized protein. (1591 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
PRRC2CProline rich coiled-coil 2C. (2875 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
RSL1D1Uncharacterized protein. (484 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1482 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1207 aa)
SRSF7Serine and arginine rich splicing factor 7. (238 aa)
MBNL1Muscleblind like splicing regulator 1. (436 aa)
AP2B1AP complex subunit beta. (951 aa)
HELLSHelicase, lymphoid specific. (824 aa)
MCM2DNA helicase; Belongs to the MCM family. (1061 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1421 aa)
PCBP2Poly(rC) binding protein 2. (331 aa)
EIF1Eukaryotic translation initiation factor 1. (113 aa)
NOM1Nucleolar protein with MIF4G domain 1. (835 aa)
KDM5BLysine demethylase 5B. (1539 aa)
NRXN2Neurexin 2. (1821 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4346 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
TRUB1TruB pseudouridine synthase family member 1. (351 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1214 aa)
SAP30BPSAP30 binding protein. (335 aa)
NSRP1Nuclear speckle splicing regulatory protein 1. (554 aa)
TMOD3Tropomodulin 3. (352 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
DNAJC2DnaJ heat shock protein family (Hsp40) member C2. (621 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
THOC3THO complex 3. (351 aa)
GET4Guided entry of tail-anchored proteins factor 4. (326 aa)
PFDN2Uncharacterized protein. (154 aa)
H1-2Histone cluster 1 H1 family member c. (227 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
CDC5LCell division cycle 5 like. (802 aa)
SRSF4Serine and arginine rich splicing factor 4. (517 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
HNRNPCRRM domain-containing protein. (299 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1102 aa)
ZC3H14Uncharacterized protein. (736 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (477 aa)
SFPQSplicing factor proline and glutamine rich. (711 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (598 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TACC1Transforming acidic coiled-coil containing protein 1. (742 aa)
PWP1PWP1 homolog, endonuclein. (500 aa)
MEF2AMADS-box domain-containing protein. (500 aa)
RBM39Uncharacterized protein. (513 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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