21 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
	VCL	Vinculin. (1134 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	P3H1	Prolyl 3-hydroxylase 1. (736 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ACTB	Uncharacterized protein. (375 aa)
	ATF4	Activating transcription factor 4. (352 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1142 aa)
	ATF6	Activating transcription factor 6. (664 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	ALB	Serum albumin. (608 aa)
	SOST	Sclerostin. (212 aa)
	CRTAP	Cartilage associated protein. (404 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	FKBP10	Peptidylprolyl isomerase. (574 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	XBP1	BZIP domain-containing protein. (261 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	ATF4	ENSCHIP00000011080	ENSCHIP00000013483	Uncharacterized protein.	Activating transcription factor 4.	0.683
ACTB	ATF6	ENSCHIP00000011080	ENSCHIP00000019493	Uncharacterized protein.	Activating transcription factor 6.	0.774
ACTB	COL1A1	ENSCHIP00000011080	ENSCHIP00000023918	Uncharacterized protein.	Collagen type I alpha 1 chain.	0.776
ACTB	DDIT3	ENSCHIP00000011080	ENSCHIP00000008843	Uncharacterized protein.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.719
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	HDAC4	ENSCHIP00000011080	ENSCHIP00000019494	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.626
ACTB	HDAC7	ENSCHIP00000011080	ENSCHIP00000009920	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.419
ACTB	PTH	ENSCHIP00000011080	ENSCHIP00000003441	Uncharacterized protein.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.515
ACTB	SOST	ENSCHIP00000011080	ENSCHIP00000021643	Uncharacterized protein.	Sclerostin.	0.530
ACTB	TGFB1	ENSCHIP00000011080	ENSCHIP00000008885	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.831
ACTB	TGFB2	ENSCHIP00000011080	ENSCHIP00000026276	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.533
ACTB	VCL	ENSCHIP00000011080	ENSCHIP00000000453	Uncharacterized protein.	Vinculin.	0.988
ACTB	XBP1	ENSCHIP00000011080	ENSCHIP00000027960	Uncharacterized protein.	BZIP domain-containing protein.	0.770
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	ATF4	ENSCHIP00000020234	ENSCHIP00000013483	Serum albumin.	Activating transcription factor 4.	0.503
ALB	ATF6	ENSCHIP00000020234	ENSCHIP00000019493	Serum albumin.	Activating transcription factor 6.	0.657
ALB	COL1A1	ENSCHIP00000020234	ENSCHIP00000023918	Serum albumin.	Collagen type I alpha 1 chain.	0.696
ALB	DDIT3	ENSCHIP00000020234	ENSCHIP00000008843	Serum albumin.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.578
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948