STRINGSTRING
HHIP HHIP PNPO PNPO IDH2 IDH2 JUN JUN SDHD SDHD VCL VCL PDHA1 PDHA1 PDXK PDXK SLC25A23 SLC25A23 OXTR OXTR ACO1 ACO1 GAS1 GAS1 GLI1 GLI1 OGDH OGDH OSBP OSBP IFT52 IFT52 GAPDH GAPDH NDUFV1 NDUFV1 LOC108638252 LOC108638252 ADCY5 ADCY5 DGAT1 DGAT1 COX6B1 COX6B1 SMO SMO MTSS1 MTSS1 NDUFA8 NDUFA8 SHH SHH NOL8 NOL8 ZIC2 ZIC2 COX8A COX8A MDH2 MDH2 PRKACB PRKACB KHK KHK NDUFB5 NDUFB5 TP53 TP53 NDUFS4 NDUFS4 PSEN2 PSEN2 CSNK1G3 CSNK1G3 PSEN1 PSEN1 FOS FOS DHCR24 DHCR24 ATP5PD ATP5PD DPYSL5 DPYSL5 STAB2 STAB2 SLC12A2 SLC12A2 ZIC1 ZIC1 CREB1 CREB1 GCHFR GCHFR ATP5F1D ATP5F1D ATP5PF ATP5PF SUFU SUFU ATP5MF ATP5MF ZIC3 ZIC3 TMEM31 TMEM31 PCCB PCCB SYS1 SYS1 SERPINE1 SERPINE1 COX15 COX15 IFT88 IFT88 PDE4A PDE4A STK36 STK36 PRKX PRKX LRP2 LRP2 MAPK11 MAPK11 STIL STIL SLC16A5 SLC16A5 PTCH2 PTCH2 CREBBP CREBBP GLI2 GLI2 PRKAA1 PRKAA1 UQCRQ UQCRQ DBNDD2 DBNDD2 IL11 IL11 ATP5MG ATP5MG BTRC BTRC IHH IHH DISP1 DISP1 BCL2 BCL2 FBXW11 FBXW11 E2F1 E2F1 THEM4 THEM4 GLI3 GLI3 UQCRC1 UQCRC1 UBQLN1 UBQLN1 MYF5 MYF5 PLAA PLAA NDUFA5 NDUFA5 ATP5F1A ATP5F1A CBY1 CBY1 GSK3B GSK3B LIFR LIFR COX7A2L COX7A2L NDUFB8 NDUFB8 NDUFB4 NDUFB4 FOXA2 FOXA2 ATP5ME ATP5ME NDUFB7 NDUFB7 SDHB SDHB CSNK1A1 CSNK1A1 TMEM185B TMEM185B AMPD2 AMPD2 DISP2 DISP2 ATP5PB ATP5PB CSNK1G2 CSNK1G2 CSNK1D CSNK1D ERI1 ERI1 CSNK1G1 CSNK1G1 SLC12A6 SLC12A6 HKDC1 HKDC1 ATP5PO ATP5PO LOC102191741 LOC102191741 RAB23 RAB23 DHH DHH NDUFA7 NDUFA7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HHIPHedgehog interacting protein. (701 aa)
PNPOPyridoxamine 5'-phosphate oxidase. (261 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
VCLVinculin. (1134 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (393 aa)
PDXKPyridoxal kinase. (321 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (900 aa)
GAS1Growth arrest specific 1. (348 aa)
GLI1GLI family zinc finger 1. (1105 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (829 aa)
IFT52Intraflagellar transport 52. (448 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
LOC108638252ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
DGAT1O-acyltransferase. (490 aa)
COX6B1Cytochrome c oxidase subunit 6B1. (99 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
MTSS1MTSS I-BAR domain containing 1. (737 aa)
NDUFA8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
NOL8Nucleolar protein 8. (1162 aa)
ZIC2Zic family member 2. (528 aa)
COX8ACytochrome c oxidase subunit 8A. (69 aa)
MDH2Malate dehydrogenase. (338 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
KHKKetohexokinase. (298 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (454 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (162 aa)
DPYSL5Dihydropyrimidinase like 5. (557 aa)
STAB2Stabilin 2. (2530 aa)
SLC12A2Solute carrier family 12 member 2. (1202 aa)
ZIC1Zic family member 1. (447 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GCHFRGTP cyclohydrolase I feedback regulator. (85 aa)
ATP5F1DATP synthase F1 subunit delta. (168 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (108 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
ATP5MFUncharacterized protein. (104 aa)
ZIC3Zic family member 3. (465 aa)
TMEM31Transmembrane protein 31. (160 aa)
PCCBPropionyl-CoA carboxylase subunit beta. (559 aa)
SYS1Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family. (156 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
COX15Cytochrome c oxidase assembly homolog COX15. (413 aa)
IFT88Intraflagellar transport 88. (825 aa)
PDE4APhosphodiesterase. (877 aa)
STK36Serine/threonine kinase 36. (1310 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (347 aa)
LRP2LDL receptor related protein 2. (4649 aa)
MAPK11Mitogen-activated protein kinase. (417 aa)
STILSTIL centriolar assembly protein. (1287 aa)
SLC16A5Solute carrier family 16 member 5. (466 aa)
PTCH2Patched 2. (1207 aa)
CREBBPCREB binding protein. (2435 aa)
GLI2GLI family zinc finger 2. (1565 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
DBNDD2Dysbindin domain containing 2. (161 aa)
IL11Interleukin 11. (191 aa)
ATP5MGATP synthase membrane subunit g. (103 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
DISP1Dispatched RND transporter family member 1. (1555 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
E2F1E2F transcription factor 1. (441 aa)
THEM4Thioesterase superfamily member 4. (268 aa)
GLI3GLI family zinc finger 3. (1614 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (480 aa)
UBQLN1Ubiquilin 1. (589 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (260 aa)
PLAAPhospholipase A2 activating protein. (796 aa)
NDUFA5NADH:ubiquinone oxidoreductase subunit A5. (108 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (560 aa)
CBY1Uncharacterized protein. (127 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
LIFRLIF receptor subunit alpha. (1066 aa)
COX7A2LCytochrome c oxidase subunit 7A2 like. (114 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
NDUFB4NADH:ubiquinone oxidoreductase subunit B4. (129 aa)
FOXA2Forkhead box A2. (467 aa)
ATP5MEUncharacterized protein. (71 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (137 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (353 aa)
TMEM185BTransmembrane protein 185B. (350 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (817 aa)
DISP2Dispatched RND transporter family member 2. (1496 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (256 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (414 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (415 aa)
ERI1Exoribonuclease 1. (349 aa)
CSNK1G1Casein kinase 1 gamma 1. (463 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
HKDC1Hexokinase domain containing 1. (918 aa)
ATP5POUncharacterized protein. (196 aa)
LOC102191741Uncharacterized protein. (152 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
NDUFA7Uncharacterized protein. (126 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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