STRINGSTRING
CSF1 CSF1 LOC102191748 LOC102191748 LOC102185882 LOC102185882 LOC108633554 LOC108633554 LOC102182848 LOC102182848 PTEN PTEN LOC108636012 LOC108636012 CTLA4 CTLA4 TBP TBP H3-4 H3-4 LOC108634231 LOC108634231 TNF TNF LOC102180554 LOC102180554 LOC106503499 LOC106503499 LOC108633916 LOC108633916 CD4 CD4 CXCL5 CXCL5 CXCL12 CXCL12 LOC102171353 LOC102171353 LOC102169981 LOC102169981 CD24 CD24 LOX LOX PPIB PPIB CXCR2 CXCR2 CD44 CD44 AR AR LOC102189503 LOC102189503 GAPDH GAPDH FOXA1 FOXA1 CXCL17 CXCL17 LOC102182683 LOC102182683 IL1B IL1B KRAS KRAS HOXB13 HOXB13 CSF1R CSF1R POLR2A POLR2A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
LOC102191748Histone domain-containing protein. (136 aa)
LOC102185882Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633554Histone domain-containing protein. (136 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
TBPUncharacterized protein. (327 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108634231Histone H3; Belongs to the histone H3 family. (136 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LOC102180554Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503499Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
CD4CD4 molecule. (455 aa)
CXCL5C-X-C motif chemokine. (119 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102169981Histone domain-containing protein. (136 aa)
CD24Uncharacterized protein. (78 aa)
LOXLysyl oxidase. (418 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
CXCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
ARAndrogen receptor. (891 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
FOXA1Forkhead box A1. (468 aa)
CXCL17Uncharacterized protein. (119 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HOXB13Homeobox B13. (285 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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