(34 nodes) (2022) Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL10	Interleukin 10. (177 aa)
	ALB	Serum albumin. (608 aa)
	LOC100860748	Hyaluronidase. (551 aa)
	IL33	Interleukin 33. (274 aa)
	LOC102168417	Hyaluronidase. (475 aa)
	IL17A	Interleukin-17A. (153 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	HYAL1	Hyaluronidase. (450 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	LOC102182683	C-X-C motif chemokine. (109 aa)
	CCL2	C-C motif chemokine. (98 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (129 aa)
	HYAL4	Hyaluronidase. (481 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	HYAL2	Hyaluronidase. (476 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (221 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	KLRG1	Killer cell lectin like receptor G1. (190 aa)
	CD80	CD80 molecule. (302 aa)
	CD4	CD4 molecule. (455 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	FOXP3	Forkhead box P3. (463 aa)
	LOC102168691	Hyaluronidase. (550 aa)
	CXCL10	C-X-C motif chemokine. (102 aa)
	CD86	Ig-like domain-containing protein. (289 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	HYAL3	Hyaluronidase. (419 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CCL2	ENSCHIP00000011080	ENSCHIP00000027804	Uncharacterized protein.	C-C motif chemokine.	0.764
ACTB	CD4	ENSCHIP00000011080	ENSCHIP00000006662	Uncharacterized protein.	CD4 molecule.	0.883
ACTB	CD80	ENSCHIP00000011080	ENSCHIP00000005477	Uncharacterized protein.	CD80 molecule.	0.679
ACTB	CD86	ENSCHIP00000011080	ENSCHIP00000015363	Uncharacterized protein.	Ig-like domain-containing protein.	0.717
ACTB	CTLA4	ENSCHIP00000011080	ENSCHIP00000003886	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.562
ACTB	CXCL10	ENSCHIP00000011080	ENSCHIP00000014303	Uncharacterized protein.	C-X-C motif chemokine.	0.738
ACTB	CXCR4	ENSCHIP00000011080	ENSCHIP00000011766	Uncharacterized protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.759
ACTB	FOXP3	ENSCHIP00000011080	ENSCHIP00000012575	Uncharacterized protein.	Forkhead box P3.	0.760
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GOT1	ENSCHIP00000011080	ENSCHIP00000029101	Uncharacterized protein.	Aspartate aminotransferase.	0.779
ACTB	GOT2	ENSCHIP00000011080	ENSCHIP00000010968	Uncharacterized protein.	Aspartate aminotransferase.	0.779
ACTB	HRAS	ENSCHIP00000011080	ENSCHIP00000002180	Uncharacterized protein.	HRas proto-oncogene, GTPase.	0.682
ACTB	HYAL1	ENSCHIP00000011080	ENSCHIP00000027713	Uncharacterized protein.	Hyaluronidase.	0.752
ACTB	HYAL2	ENSCHIP00000011080	ENSCHIP00000003847	Uncharacterized protein.	Hyaluronidase.	0.752
ACTB	HYAL3	ENSCHIP00000011080	ENSCHIP00000016919	Uncharacterized protein.	Hyaluronidase.	0.749
ACTB	HYAL4	ENSCHIP00000011080	ENSCHIP00000001850	Uncharacterized protein.	Hyaluronidase.	0.750
ACTB	IFNG	ENSCHIP00000011080	ENSCHIP00000016152	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.875
ACTB	IL10	ENSCHIP00000011080	ENSCHIP00000016929	Uncharacterized protein.	Interleukin 10.	0.865
ACTB	IL15	ENSCHIP00000011080	ENSCHIP00000029315	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.583