14 items (Capra hircus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	FANCF	FA complementation group F. (359 aa)
	MSH3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa)
	DDB2	Damage specific DNA binding protein 2. (411 aa)
	SLX1A	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (267 aa)
	DNA2	DNA replication helicase/nuclease 2. (1062 aa)
	BRD4	Uncharacterized protein. (1336 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (887 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	VTN	SMB domain-containing protein. (475 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
	ACTB	Uncharacterized protein. (375 aa)
	EXO1	Exonuclease 1. (835 aa)
	RNF2	RING-type domain-containing protein. (336 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	BRD4	ENSCHIP00000011080	ENSCHIP00000020041	Uncharacterized protein.	Uncharacterized protein.	0.582
ACTB	DDB2	ENSCHIP00000011080	ENSCHIP00000024487	Uncharacterized protein.	Damage specific DNA binding protein 2.	0.444
ACTB	EXO1	ENSCHIP00000011080	ENSCHIP00000010493	Uncharacterized protein.	Exonuclease 1.	0.400
ACTB	VTN	ENSCHIP00000011080	ENSCHIP00000012947	Uncharacterized protein.	SMB domain-containing protein.	0.647
BRD4	ACTB	ENSCHIP00000020041	ENSCHIP00000011080	Uncharacterized protein.	Uncharacterized protein.	0.582
DDB2	ACTB	ENSCHIP00000024487	ENSCHIP00000011080	Damage specific DNA binding protein 2.	Uncharacterized protein.	0.444
DDB2	EXO1	ENSCHIP00000024487	ENSCHIP00000010493	Damage specific DNA binding protein 2.	Exonuclease 1.	0.584
DDB2	FEN1	ENSCHIP00000024487	ENSCHIP00000005017	Damage specific DNA binding protein 2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.696
DDB2	MSH6	ENSCHIP00000024487	ENSCHIP00000012330	Damage specific DNA binding protein 2.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.650
DNA2	EXO1	ENSCHIP00000020258	ENSCHIP00000010493	DNA replication helicase/nuclease 2.	Exonuclease 1.	0.990
DNA2	FEN1	ENSCHIP00000020258	ENSCHIP00000005017	DNA replication helicase/nuclease 2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.985
DNA2	MSH3	ENSCHIP00000020258	ENSCHIP00000032746	DNA replication helicase/nuclease 2.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.423
DNA2	MSH6	ENSCHIP00000020258	ENSCHIP00000012330	DNA replication helicase/nuclease 2.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.604
DNA2	PCNA	ENSCHIP00000020258	ENSCHIP00000015091	DNA replication helicase/nuclease 2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.723
DNA2	SLX1A	ENSCHIP00000020258	ENSCHIP00000023499	DNA replication helicase/nuclease 2.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.	0.882
EXO1	ACTB	ENSCHIP00000010493	ENSCHIP00000011080	Exonuclease 1.	Uncharacterized protein.	0.400
EXO1	DDB2	ENSCHIP00000010493	ENSCHIP00000024487	Exonuclease 1.	Damage specific DNA binding protein 2.	0.584
EXO1	DNA2	ENSCHIP00000010493	ENSCHIP00000020258	Exonuclease 1.	DNA replication helicase/nuclease 2.	0.990
EXO1	FEN1	ENSCHIP00000010493	ENSCHIP00000005017	Exonuclease 1.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.868
EXO1	MSH3	ENSCHIP00000010493	ENSCHIP00000032746	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.959