STRINGSTRING
RPL22 RPL22 LOC102191748 LOC102191748 LOC102185882 LOC102185882 LOC108633554 LOC108633554 LOC102182848 LOC102182848 LOC108636012 LOC108636012 RNF8 RNF8 H3-4 H3-4 LOC108634231 LOC108634231 LOC102180554 LOC102180554 LOC106503499 LOC106503499 LOC108633916 LOC108633916 SETDB1 SETDB1 LOC102171353 LOC102171353 EEF1D EEF1D LOC102169981 LOC102169981 MDC1 MDC1 STRA8 STRA8 BRDT BRDT LOC102189503 LOC102189503 EEF1G EEF1G GAPDH GAPDH USP7 USP7 TNP1 TNP1 SYCP3 SYCP3 TOPBP1 TOPBP1 EEF1B2 EEF1B2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL22Ribosomal protein L22. (128 aa)
LOC102191748Histone domain-containing protein. (136 aa)
LOC102185882Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633554Histone domain-containing protein. (136 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108634231Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102180554Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503499Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1287 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
EEF1DUncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family. (280 aa)
LOC102169981Histone domain-containing protein. (136 aa)
MDC1Mediator of DNA damage checkpoint 1. (1914 aa)
STRA8Stimulated by retinoic acid 8. (447 aa)
BRDTBromodomain testis associated. (909 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
EEF1GUncharacterized protein. (440 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
TNP1Transition protein 1. (55 aa)
SYCP3Synaptonemal complex protein 3. (229 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
EEF1B2Uncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family. (225 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.