26 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
	CSF2	Granulocyte-macrophage colony stimulating factor. (144 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	XBP1	BZIP domain-containing protein. (261 aa)
	TRIB3	Tribbles pseudokinase 3. (357 aa)
	SLC7A5	Solute carrier family 7 member 5. (505 aa)
	ATF6	Activating transcription factor 6. (664 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	LOC102190507	Uncharacterized protein. (139 aa)
	THPO	Thrombopoietin. (353 aa)
	JDP2	Jun dimerization protein 2. (163 aa)
	SLC7A1	Solute carrier family 7 member 1. (629 aa)
	SRSF2	RRM domain-containing protein. (221 aa)
	PRMT5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
	RPLP0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
	PRMT1	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
	ATF4	Activating transcription factor 4. (352 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	ACTB	Uncharacterized protein. (375 aa)
	UPF1	UPF1 RNA helicase and ATPase. (1126 aa)
	SRSF1	Uncharacterized protein. (248 aa)
	TBP	Uncharacterized protein. (327 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ATF4	ENSCHIP00000011080	ENSCHIP00000013483	Uncharacterized protein.	Activating transcription factor 4.	0.683
ACTB	ATF6	ENSCHIP00000011080	ENSCHIP00000019493	Uncharacterized protein.	Activating transcription factor 6.	0.774
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	CSF2	ENSCHIP00000011080	ENSCHIP00000033907	Uncharacterized protein.	Granulocyte-macrophage colony stimulating factor.	0.769
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	LOC102190507	ENSCHIP00000011080	ENSCHIP00000018311	Uncharacterized protein.	Uncharacterized protein.	0.658
ACTB	PRMT5	ENSCHIP00000011080	ENSCHIP00000016914	Uncharacterized protein.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.557
ACTB	PTEN	ENSCHIP00000011080	ENSCHIP00000002897	Uncharacterized protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.844
ACTB	RPLP0	ENSCHIP00000011080	ENSCHIP00000014261	Uncharacterized protein.	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	0.787
ACTB	TBP	ENSCHIP00000011080	ENSCHIP00000003904	Uncharacterized protein.	Uncharacterized protein.	0.876
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ACTB	TRIB3	ENSCHIP00000011080	ENSCHIP00000022310	Uncharacterized protein.	Tribbles pseudokinase 3.	0.408
ACTB	XBP1	ENSCHIP00000011080	ENSCHIP00000027960	Uncharacterized protein.	BZIP domain-containing protein.	0.770
ASNS	ATF4	ENSCHIP00000012001	ENSCHIP00000013483	Asparagine synthetase [glutamine-hydrolyzing].	Activating transcription factor 4.	0.819
ASNS	ATF6	ENSCHIP00000012001	ENSCHIP00000019493	Asparagine synthetase [glutamine-hydrolyzing].	Activating transcription factor 6.	0.463
ASNS	PHGDH	ENSCHIP00000012001	ENSCHIP00000019405	Asparagine synthetase [glutamine-hydrolyzing].	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.818
ASNS	SHMT2	ENSCHIP00000012001	ENSCHIP00000001693	Asparagine synthetase [glutamine-hydrolyzing].	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.806
ASNS	SLC7A1	ENSCHIP00000012001	ENSCHIP00000017181	Asparagine synthetase [glutamine-hydrolyzing].	Solute carrier family 7 member 1.	0.493
ASNS	SLC7A5	ENSCHIP00000012001	ENSCHIP00000021590	Asparagine synthetase [glutamine-hydrolyzing].	Solute carrier family 7 member 5.	0.639
ASNS	TRIB3	ENSCHIP00000012001	ENSCHIP00000022310	Asparagine synthetase [glutamine-hydrolyzing].	Tribbles pseudokinase 3.	0.808