STRINGSTRING
KRT18 KRT18 XBP1 XBP1 KRT19 KRT19 CDX2 CDX2 PDGFRB PDGFRB SOX11 SOX11 TP53 TP53 NES NES CSF1R CSF1R PAX2 PAX2 FGA-2 FGA-2 FOXC1 FOXC1 CREB3L1 CREB3L1 BATF BATF XCR1 XCR1 CD4 CD4 FOXA3 FOXA3 IRX2 IRX2 IRF7 IRF7 NFIA NFIA AGR2 AGR2 NR5A2 NR5A2 FCN1 FCN1 MEIS2 MEIS2 FOXP3 FOXP3 IRX3 IRX3 SPP1 SPP1 MECOM MECOM ATF3 ATF3 EPHA2 EPHA2 CD163 CD163 PPARG PPARG SERPINE2 SERPINE2 ZEB1 ZEB1 SYNE1 SYNE1 ASGR1 ASGR1 APOB APOB EN2 EN2 OASL OASL HOXB7 HOXB7 CREB5 CREB5 LGR5 LGR5 FGA FGA ONECUT1 ONECUT1 CDH2 CDH2 COL12A1 COL12A1 OAS1 OAS1 ID4 ID4 MDK MDK COL1A1 COL1A1 EGR1 EGR1 CD68 CD68
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
XBP1BZIP domain-containing protein. (261 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (399 aa)
CDX2Caudal type homeobox 2. (306 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
SOX11Transcription factor SOX. (444 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
NESNestin; Belongs to the intermediate filament family. (1606 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
PAX2Paired box 2. (467 aa)
FGA-2Fibrinogen C-terminal domain-containing protein. (206 aa)
FOXC1Forkhead box C1. (543 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (581 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CD4CD4 molecule. (455 aa)
FOXA3Forkhead box A3. (347 aa)
IRX2Iroquois homeobox 2. (482 aa)
IRF7Interferon regulatory factor 7. (480 aa)
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (509 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (547 aa)
FCN1Ficolin 1. (329 aa)
MEIS2Meis homeobox 2. (470 aa)
FOXP3Forkhead box P3. (463 aa)
IRX3Iroquois homeobox 3. (503 aa)
SPP1Uncharacterized protein. (279 aa)
MECOMMDS1 and EVI1 complex locus. (1123 aa)
ATF3Activating transcription factor 3. (181 aa)
EPHA2EPH receptor A2. (975 aa)
CD163CD163 molecule. (1114 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8801 aa)
ASGR1Asialoglycoprotein receptor 1. (286 aa)
APOBApolipoprotein B. (4620 aa)
EN2Homeobox protein engrailed-like. (324 aa)
OASL25A_SYNTH_3 domain-containing protein. (342 aa)
HOXB7Homeobox B7. (217 aa)
CREB5cAMP responsive element binding protein 5. (549 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
FGAFibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (618 aa)
ONECUT1One cut domain family member. (464 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
COL12A1Collagen type XII alpha 1 chain. (3046 aa)
OAS12'-5'-oligoadenylate synthetase 1. (390 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (272 aa)
MDKMidkine. (143 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
CD68CD68 molecule. (335 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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