STRINGSTRING
SMAD9 SMAD9 SYP SYP TGFB3 TGFB3 JAK2 JAK2 CDKN1A CDKN1A ITGB4 ITGB4 PTEN PTEN EZH2 EZH2 NFKB1 NFKB1 STAT1 STAT1 BBC3 BBC3 NEO1 NEO1 SOX2 SOX2 RNF2 RNF2 TGFB1 TGFB1 ASCL1 ASCL1 BIRC5 BIRC5 NEUROD1 NEUROD1 SMAD5 SMAD5 JAKMIP2 JAKMIP2 TM4SF1 TM4SF1 TEAD1 TEAD1 PIK3C3 PIK3C3 CHGA CHGA E2F1 E2F1 ETS1 ETS1 ZEB1 ZEB1 IFNG IFNG KLF4 KLF4 FXR1 FXR1 BMPR1B BMPR1B HOXB1 HOXB1 BRAF BRAF LEP LEP MDM2 MDM2 MTOR MTOR STAT3 STAT3 VIM VIM EGFR EGFR ANXA1 ANXA1 AR AR GAPDH GAPDH TGFB2 TGFB2 EPCAM EPCAM FOXA1 FOXA1 PAX7 PAX7 CCL2 CCL2 SNAI2 SNAI2 TMPRSS2 TMPRSS2 TP53 TP53 PRKCI PRKCI HOXB13 HOXB13 BRCA1 BRCA1 MED12 MED12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD9Mothers against decapentaplegic homolog. (461 aa)
SYPSynaptophysin. (313 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
ITGB4Integrin beta. (1850 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
BBC3Uncharacterized protein. (193 aa)
NEO1Neogenin 1. (1472 aa)
SOX2HMG box domain-containing protein. (320 aa)
RNF2RING-type domain-containing protein. (336 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
BIRC5Uncharacterized protein. (142 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
JAKMIP2Janus kinase and microtubule interacting protein 2. (859 aa)
TM4SF1Transmembrane 4 L six family member 1. (202 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
CHGAChromogranin A. (534 aa)
E2F1E2F transcription factor 1. (441 aa)
ETS1Uncharacterized protein. (485 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
KLF4Kruppel like factor 4. (510 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
HOXB1Homeobox B1. (302 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (774 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
VIMVimentin; Belongs to the intermediate filament family. (471 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
ANXA1Annexin. (346 aa)
ARAndrogen receptor. (891 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
FOXA1Forkhead box A1. (468 aa)
PAX7Paired box 7. (503 aa)
CCL2C-C motif chemokine. (98 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
HOXB13Homeobox B13. (285 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
MED12Med12 domain-containing protein. (2040 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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